CLINICAL ASPECTS FOR USE OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS IN COMBINATION WITH METFORMIN: BENEFITS FOR DIFFERENT GROUPS OF PATIENTS
- Authors: Antsiferov M.B.1, Antsiferov MB1
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Affiliations:
- Issue: No 3 (2011)
- Pages: 50-55
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/278802
- ID: 278802
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Abstract
Mechanisms of action and potentials for use of dipeptidyl peptidase-4 (DPP-4) inhibitor vildagliptin (Galvus) and its combined form with metformin (Galvus Met) in type 2 diabetes mellitus (DM2) are discussed. The article presents the results of numerous clinical trials that have proved efficacy of DPP-4 inhibitors, primarily Galvus and Galvus Met, in improvement of glycemic control without increasing body weight and frequency of hypoglycaemia. They can be used in combination with all oral hypoglycemic agents and insulin (vildagliptin) that expands the range of use due to different groups of patients with DM2.
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