Email this article The use of liquid probiotic complexes in children: A review
- Authors: Kholodova I.N.1, Akopian A.N.2
-
Affiliations:
- Russian Medical Academy of Continuous Professional Education
- LLC «Health. Genotek»
- Issue: No 2 (2026)
- Pages: 114-117
- Section: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/708369
- DOI: https://doi.org/10.26442/26586630.2026.2.203739
- ID: 708369
Cite item
Full Text
Abstract
The composition of the intestinal microbiota significantly influences the progression of various pathological processes within the human body. There is now clear evidence supporting the role of dysbiosis in the emergence of functional gastrointestinal disorders in young children. This article examines the current understanding of the treatment of these disorders in children using liquid probiotic complexes—specifically, the Normoflorin synbiotics. These synbiotic complexes comprise live and physiologically active lactobacilli and bifidobacteria (Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium bifidum), along with their metabolic products, including short-chain fatty acids, enzymes, and vitamins. Liquid probiotic formulations can colonize the intestine more rapidly (within 2 hours) than lyophilized formulations. Clinical observations demonstrate the beneficial effects of Normoflorin synbiotics for conditions such as lactase deficiency, atopic dermatitis, and functional gastrointestinal disorders in children, suggesting that these agents may serve as a promising adjunct to therapy; however, further randomized studies are needed to confirm these findings.
Full Text
About the authors
Irina N. Kholodova
Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: chin5@yandex.ru
ORCID iD: 0000-0003-0090-6980
D. Sci. (Med.)
Russian Federation, MoscowAiarpi N. Akopian
LLC «Health. Genotek»
Email: chin5@yandex.ru
ORCID iD: 0009-0002-2461-0156
Cand. Sci. (Med.)
Russian Federation, MoscowReferences
- Пучкова А.А., Дегтярева А.В., Жданова С.И., Голубцова Ю.М. Младенческие колики: современный взгляд на патогенетические механизмы и лечебные мероприятия (обзор). Неонатология: Новости. Мнения. Обучение. 2021;9(1): 50-9 [Puchkova AA, Degtyareva AV, Zhdanova SI, Golubtsova YuM. Infant colic: a new look at pathogenetic mechanisms and therapeutic measures (literature review). Neonatology: News, Opinions, Training. 2021;9(1):50-9 (in Russian)]. doi: 10.33029/2308-2402-2021-9-1-50-59
- Панова Л.Д. Младенческие колики: где грань между нормой и патологией? Роль нарушения микробиома кишечника. Медицинский Совет. 2021;(17):246-54 [Panova LD. Infant colic: where is the line between norm and pathology, the role of disruption of the intestinal microbiome. Meditsinskiy sovet = Medical Council. 2021;(17):246-54 (in Russian)]. doi: 10.21518/2079-701x-2021-17-246-254
- Szajewska H, Berni Canani R, Domellöf M, et al. Probiotics for the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications. J Pediatr Gastroenterol Nutr. 2023;76(2):232-47. doi: 10.1097/MPG.0000000000003633
- Sung V, D'Amico F, Cabana MD, et al. Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis. Pediatrics. 2017;141(1):e20171811. doi: 10.1542/peds.2017-1811
- Indrio F, Di Mauro A, Riezzo G, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr. 2014;168(3):228-33. doi: 10.1001/jamapediatrics.2013.4367
- Hill C, Guarner F, Reid G, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-14. doi: 10.1038/nrgastro.2014.66
- Baldassarre ME, Di Mauro A, Tafuri S, et al. Effectiveness and Safety of a Probiotic-Mixture for the Treatment of Infantile Colic: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial with Fecal Real-Time PCR and NMR-Based Metabolomics Analysis. Nutrients. 2018;10(2):195. doi: 10.3390/nu10020195
- Холодова И.Н., Ильенко Л.И., Демин В.Ф., и др. Новые возможности диагностики и лечения дисбиотических нарушений кишечника у детей. РМЖ. 2003;20:1124 [Kholodova IN, Il'enko LI, Demin VF, et al. Novye vozmozhnosti diagnostiki i lecheniia disbioticheskikh narushenii kishechnika u detei. Russian Medical Journal. 2003;20:1124 (in Russian)].
- Report of a Joint FAO/WHO Expert Consultation on Evaluation of Healthand Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria. Available at: http://www.fao.org/3/a-a0512e.pdf. Accessed: 09.03.2026.
- Kianifar H, Ahanchian H, Grover Z, et al. Synbiotic in the management of infantile colic: a randomised controlled trial. J Paediatr Child Health. 2014;50(10):801-5. doi: 10.1111/jpc.12640
- Герасимчук Е.В. Применение жидких пробиотиков. Режим доступа: https://medband.ru/article/14/103. Ссылка активна на 14.03.2026 [Gerasimchuk EV. Primenenie zhidkikh probiotikov. Available at: https://medband.ru/article/14/103. Accessed: 09.03.2026 (in Russian)].
- Вахлова И.В., Федотова Г.В., Боронина Л.Г., Ибрагимова Ю.Н. Физическое развитие и его связь с метаболической активностью микробиоты кишечника у детей раннего возраста. Уральский медицинский журнал. 2021;20(5):35-42 [Vakhlova IV, Fedotova GV, Boronina LG, Ibragimova YN. Physical development and its relationship to the metabolic activity of the intestinal microbiota in young children. Ural Medical Journal. 2021;20(5):35-42 (in Russian)]. doi: 10.52420/2071-5943-2021-20-5-35-42
- Бельмер С.В., Хавкин А.И. Кишечная микробиота у детей: норма, нарушения, коррекция. М.: Медпрактика-М, 2019; c. 44-5 [Bel'mer SV, Khavkin AI. Kishechnaia mikrobiota u detei: norma, narusheniia, korrektsiia. Moscow: Medpraktika-M, 2019; p. 44-5 (in Russian)].
- Бельмер С.В., Ардатская М.Д., Акопян А.Н. Короткоцепочечные жирные кислоты в лечении функциональных заболеваний кишечника у детей: теоретическое обоснование и практическое применение. М.: Прима Принт, 2015. 48 с. [Bel'mer SV, Ardatskaia MD, Akopian AN. Korotkotsepochechnye zhirnye kisloty v lechenii funktsional'nykh zabolevanii kishechnika u detei: teoreticheskoe obosnovanie i prakticheskoe primenenie. Moscow: Prima Print, 2015. 48 p. (in Russian)].
- Лупаш Н.Г., Майорова А.В., Маймескулова И.В., Кривошеева И.Ю. Применение синбиотика нормофлорины при атопическом дерматите с сопутствующей патологией желудочно-кишечного тракта у детей. Кубанский научный медицинский вестник. 2012;5(134):48-52 [Lupash NG, Mayorova AV, Maymeskulova IV, Krivosheeva IY. Synbiotica normoflorina’s application at atopic dermatitis with accompanying pathology of the gastroenteric path at children. Kuban Scientific Medical Bulletin. 2012;5(134):48-52 (in Russian)].
- Сугян Н.Г., Ваулина О.В. Жидкие синбиотики Нормофлорины в лечении лактазной недостаточности у детей. Поликлиника. 2006;1:18-9 [Sugian NG, Vaulina OV. Zhidkie sinbiotiki Normofloriny v lechenii laktaznoi nedostatochnosti u detei. Poliklinika. 2006;1:18-9 (in Russian)].
- Ардатская М.Д., Зверков И.В., Масловский Л.В., и др. Эффективность синбиотических биокомплексов в коррекции нарушений кишечного микробиоценоза. Медицинский Совет. 2026;(23):64-73 [Ardatskaya MD, Zverkov IV, Maslovskii LV, et al. Effectiveness of synbiotic biocomplexes in correction of gut microbiocenosis disorders. Meditsinskiy sovet = Medical Council. 2026;(23): 64-73 (in Russian)]. doi: 10.21518/ms2025-529
- Баранов К.К., Акопян А.Н. Профилактика развития антибиотик-ассоциированной диареи у пациентов, получавших системную антибактериальную терапию по поводу оториноларингологических заболеваний. Детская оториноларингология. 2024;1–2:34-7 [Baranov KK, Akopian AN. Profilaktika razvitiia antibiotik-assotsiirovannoi diarei u patsientov, poluchavshikh sistemnuiu antibakterial'nuiu terapiiu po povodu otorinolaringologicheskikh zabolevanii. Detskaia otorinolaringologiia. 2024;1–2:34-7 (in Russian)].
Supplementary files
