Pediatrics. Consilium MedicumPediatrics. Consilium MedicumПедиатрия. Consilium Medicum2658-66302658-6622Consilium Medicum10063110.26442/26586630.2021.4.201341ArticlesСтатьиReview ArticleGut microbiota and obesity. Can probiotics help?Микробиота кишечника и ожирение. Могут ли помочь пробиотики?https://orcid.org/0000-0003-4200-4598ZakharovaIrina N.ЗахароваИрина Николаевна
Russian Federation

D. Sci. (Med.), Prof.

д-р мед. наук, проф., зав. каф. педиатрии, засл. врач России

zakharova-rmapo@yandex.ruhttps://orcid.org/0000-0001-5684-7575BerezhnayaIrina V.БережнаяИрина Владимировна
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук, доц. каф. педиатрии

berezhnaya-irina26@yandex.ruhttps://orcid.org/0000-0002-7994-3751SimakovaMariia A.СимаковаМария Александровна
Russian Federation

Graduate Student

аспирант каф. педиатрии

simakova131@mail.ruRussian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России1512202143303341302202213022022Copyright ©; 2021, Consilium MedicumCopyright ©; 2021, ООО "Консилиум Медикум"2021Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://pediatria.orscience.ru/2658-6630/article/view/100631

The high prevalence of obesity in children and adolescents, the complexity of therapy, a large number of comorbid conditions dictate the need for ongoing research into the causes of obesity and methods for its prevention. One of the newest and most promising aspects to study influencing the formation of obesity is the gut microbiota. The proposed mechanisms linking the gut microbiota to obesity are realized through strain-specific effects of bacteria on changes in the host's metabolism. Probiotics affect the microbiota directly by modulating its composition and indirectly through bacteriocins produced by probiotic bacteria. There is great scientific interest in the use of probiotics as part of therapy or for the prevention of obesity.

Высокая распространенность ожирения среди детей и подростков, сложность терапии, большое количество коморбидных состояний диктуют необходимость постоянного изучения причин развития ожирения и методов его профилактики. К одним из наиболее новых и перспективных аспектов для изучения, влияющих на формирование ожирения, относят микробиоту кишечника. Предлагаемые механизмы, связывающие микробиоту кишечника с ожирением, реализуются через штамм-специфичное влияние бактерий на изменения метаболизма организма-хозяина. Пробиотики воздействуют на микробиоту напрямую, модулируя ее состав, и косвенно – через бактериоцины, продуцируемые пробиотическими бактериями. Большой научный интерес вызывает применение пробиотиков в составе терапии или для профилактики ожирения.

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