Pediatrics. Consilium MedicumPediatrics. Consilium MedicumПедиатрия. Consilium Medicum2658-66302658-6622Consilium Medicum5707610.26442/26586630.2020.1.200122ArticlesСтатьиReview ArticlePEDIATRIC QUESTIONS ABOUT A NEW CORONAVIRUS INFECTION -ARE THERE ANY ANSWERS TODAY?ПЕДИАТРИЧЕСКИЕ ВОПРОСЫ О НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ - ЕСТЬ ЛИ НА НИХ СЕГОДНЯ ОТВЕТЫ?ZaplatnikovAndrei L.ЗАПЛАТНИКОВАНДРЕЙ ЛЕОНИДОВИЧ

д-р мед. наук, проф., зав. каф. неонатологии

zaplatnikov@mail.ruGorevValerii V.ГОРЕВВАЛЕРИЙ ВИКТОРОВИЧ

канд. мед. наук, доц. каф. неонатологии

DmitrievAndrei V.ДМИТРИЕВАНДРЕЙ ВЛАДИМИРОВИЧDement'evAleksandr A.ДЕМЕНТЬЕВА. А

канд. мед. наук, доц. каф. неонатологии

ChabaidzeZhuzhuna L.ЧАБАИДЗЕЖУЖУНА ЛАЗОРЕВНА

канд. мед. наук, доц. каф. неонатологии

SvintsitskaiaViktoriia I.СВИНЦИЦКАЯВИКТОРИЯ ИОСИФОВНА

канд. мед. наук, доц. каф. педиатрии

Russian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииDepartment of Health of MoscowДепартамент здравоохранения г. МосквыPavlov Ryazan State Medical UniversityФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России150320201NO1 (2020)№1 (2020)161929122020Copyright ©; 2020, Consilium MedicumCopyright ©; 2020, ООО "Консилиум Медикум"2020Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://pediatria.orscience.ru/2658-6630/article/view/57076

A review of the literature on the main features of the new coronavirus infection in children is presented. It is noted that to date there is no convincing evidence in favor of vertical infection, while the possibility of horizontal transmission of the infection from mother to her newborn child has been shown. The main provisions of the agreed recommendations of international and national professional medical communities on tactics of managing newborn babies from mothers with COVID-19 (Coronavirus disease 2019) are presented. It was shown that in the structure of patients with severe COVID-19, the share of children is no more than 5%. It has been established that in children the new coronavirus infection in the vast majority of cases is asymptomatic or mild. The main hypotheses of a milder course of COVID-19 in pediatric patients are presented. Moreover, it is emphasized that children with asymptomatic and mild disease constitute the main vector-borne potential for the continuation of the pandemic.

Представлен обзор литературы, посвященный основным особенностям новой коронавирусной инфекции у детей. Отмечено, что до настоящего времени нет убедительных данных в пользу вертикального инфицирования, в то время как показана возможность горизонтальной передачи инфекции от матери ее новорожденному ребенку. Приводятся основные положения согласованных рекомендаций международных и национальных профессиональных медицинских сообществ по тактике ведения новорожденных детей от матерей с COVID-19 (Coronavirus disease 2019). Показано, что в структуре пациентов с тяжелым течением COVID-19 на долю детей приходится не более 5%. Установлено, что у детей новая корона-вирусная инфекция в подавляющем большинстве случаев протекает бессимптомно или в легкой форме. Представлены основные гипотезы более легкого течения COVID-19 у педиатрических пациентов. При этом особо подчеркивается, что дети с бессимптомным и легким течением заболевания составляют основной трансмиссивный потенциал для продолжения пандемии.

COVID-19childrennew coronavirus infectionnewbornsCOVID-19детиновая коронавирусная инфекцияноворожденные детиWorld Health Organization (WHO) Coronavirus disease (COVID-19) pandemic. https://www.who.int/emergencies/diseases/novel-coronavirus-2019Mascio D, Asma K, Saccone G. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1-19) during pregnancy:a systematic review and meta-analysis. Am J Obstet Gynecol 2020. https://doi.org/10.1016/j.ajogmf.2020.100107World Health Organization (WHO) Q&A on COVID-19, pregnancy, childbirth and breastfeeding. https://www.who.int/news-room/q-a-detail/q-a-on-covid-19-pre-gnancy-childbirth-and-breastfeedingCOVID-19 and Breastfeeding Position Paper. European Paediatric Association, the Union of National European Paediatric Societies and Associations (EPA/UNEPSA). https://r.epa-unepsa.eu/i/sSSE9qOATiQSgn-7s12OA1kqh62ccuewChen H, Guo J, Wang C et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395 (10226): 809-15.Zeng L, Xia S, Yuan W et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics Published online March 26, 2020. DOI: 10.1001/jamapediatrics.2020.0878Zhu H, Wang L, Fang C et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV. Transl Pediatr 2020; 9 (1): 51-60. http://dx.dororg/10.21037/tp.2020.02.06Wang L, Shi Y, Xiao T. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) Ann Transl Med 2020; 8 (3): 47. http://dx.doi.org/10.21037/atm.2020.02.20Li N, Han L, Peng M et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Med Rxiv 2020. https://doi.org/1 0.1 1 01 /2020.03.1 0.20033605(2020); https://www.medrxiv.org/content/10.1101/2020.03.10.20033605v1.full.pdf+htmlLiu W, Wang Q, Zhang Q et al. Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Preprints 2020; 2020020373. https://www.preprints.org/manuscript/202002.0373/v1Dashraath P, Jing LJW, Mei XL et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020 Mar 23. DOI: 10.1016/j.ajog.2020.03.021. https://www.ncbi.nlm.nih.gov/pubmed/32217113Chen Y, Peng H, Wang L et al. Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr 2020; 8: 104. DOI: 10.3389/fped.2020.00104Wang J, Wang D, Chen GC et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate Zhongguo Dang Dai Er Ke Za Zhi 2020; 22 (3): 211-4.Schwartz DA An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med 2020 Mar 17. DOI: 10.5858/arpa.2020-0901-SA. https://www.ncbi.nlm.nih.gov/pubmed/32180426AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19. Alyson Sulaski Wyckoff, Associate Editor April 02, 2020. https://www.aappublications.org/news/2020/04/02/infantcovidguidance040220Liu W, Zhang Q, Chen J et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020 Mar 12. DOI: 10.1056/NEJMc2003717. https://wwwnejm.org/doi/10.1056/NEJMc2003717Chan JF, Yuan S, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395: 514-23. https://www.scopus.com/record/display.uri?eid=2-s2.0-85078241697&origin=inward&txGid=55db2921548fb8968482129191a2e0caZhang YP. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chin J Epidemiol 2020; 41: 145-51.Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020; 119 (3): 670-3. DOI: 10.1016/j.jfma.2020.02.009. https://www.ncbi.nlm.nih.gov/pubmed/32139299Lu X, Zhang L, Du H et al. SARS-CoV-2 infection in children. N Engl J Med 2020 Mar 18. https://doi.org/10.1056/NEJMc2005073Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr 2020 Mar 23. DOI: 10.1111/apa.15270. https://www.ncbi.nlm.nih.gov/pubmed/32202343Lee PI, Hu YL, Chen PY et al. Are children less susceptible to COVID-19? J Microbiol Immunol Infect 2020 Feb 25. DOI: 10.1016/j.jmii.2020.02.011. https://www.scien-cedirect.com/science/journal/16841182Gu H, Xie Z, Li T et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep 2016; 6: 19840.Dong Y, Mo Х, Hu Y et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020 March. https://doi.org/10.1542/peds.2020-0702Hagmann S. COVID-19 in children: More than meets the eye. Travel Med Infect Dis 2020 March 28. https://www.sciencedirect.com/science/article/pii/ S1477893920301174?via%3Dihub