Pediatrics. Consilium MedicumPediatrics. Consilium MedicumПедиатрия. Consilium Medicum2658-66302658-6622Consilium Medicum5709610.26442/26586630.2020.2.200238ArticlesСтатьиReview ArticleInfluence of vitamin D on the immune response of the organismВлияние витамина D на иммунный ответ организмаZakharovaIrina N.ЗахароваИрина Николаевна

д-р мед. наук, проф., зав. каф. педиатрии

zakharova-rmapo@yandex.ruMaltsevStanislav V.МальцевСтанислав Викторович

д-р мед. наук, проф., проф. каф. педиатрии

ZaplatnikovAndrei L.ЗаплатниковАндрей Леонидович

д-р мед. наук, проф., проректор по учебной работе, зав. каф. неонатологии

KlimovLeonid Ya.КлимовЛеонид Яковлевич

д-р мед. наук, доц., зав. каф. факультетской педиатрии

PampuraAleksandr N.ПампураАлександр Николаевич

д-р мед. наук, рук. отд. аллергологии и клинической иммунологии

KuryaninovaViktoriia A.КурьяниноваВиктория Александровна

канд. мед. наук, доц. каф. пропедевтики детских болезней

BerezhnayaIrina V.БережнаяИрина Владимировна

канд. мед. наук, доц. каф. педиатрии

ZhdakaevaEkaterina D.ЖдакаеваЕкатерина Дмитриевна

ординатор каф. педиатрии

SimakovaMariia A.СимаковаМария Александровна

аспирант каф. педиатрии

TsutsaevaAnna N.ЦуцаеваАнна Николаевна

канд. мед. наук, ассистент каф. факультетской педиатрии

DolbnyaSvetlana V.ДолбняСветлана Викторовна

канд. мед. наук, доц. каф. факультетской педиатрии

VerisokinaNatalia E.ВерисокинаНаталья Евгеньевна

ассистент каф. факультетской педиатрии

KrushelnitskyAnatolii A.КрушельницкийАнатолий Александрович

анестезиолог-реаниматолог, неонатолог отд-ния реанимации и интенсивной терапии новорожденных

MakhaevaAnastasiia V.МахаеваАнастасия Владимировна

зав. 2-м педиатрическим отд-нием

SychevDmitrii A.СычевДмитрий Алексеевич

чл.-кор. РАН, д-р мед. наук, проф., ректор, зав. каф. клинической фармакологии и терапии

Russian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииStavropol State Medical UniversityФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава РоссииPirogov Russian National Research Medical UniversityФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииShchyolkovo Perinatal CenterГБУЗ МО «Щелковский перинатальный центр»Children's City Clinic №140ГБУЗ «Детская городская поликлиника №140» Департамента здравоохранения г. Москвы150620202NO2 (2020)№2 (2020)293729122020Copyright ©; 2020, Consilium MedicumCopyright ©; 2020, ООО "Консилиум Медикум"2020Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://pediatria.orscience.ru/2658-6630/article/view/57096

A literature review is devoted to the effect of vitamin D on the body's immune response. Studies show that vitamin D is able to inhibit the synthesis of pro-inflammatory cytokines, and, as a result, play an important role in the formation of immune tolerance, which is important in infectious, autoimmune diseases and in patients after organ transplantation. Vitamin D can be used both as a prophylaxis and for therapeutic purposes for infectious diseases, in oncohematology, allergology, gastroenterology, and can also affect the intrauterine development of the fetus and the immune response of the newborn, reducing the risk of pregnancy pathology, risks of premature birth and placenta pathology, as well as reducing the frequency, severity and risk of adverse outcome in newborns with congenital and acquired infectious diseases. In the postnatal period, normal provision with vitamin D not only reduces the frequency, but also prevents the formation of severe forms of autoimmune, allergic diseases in children and adolescents.

Литературный обзор посвящен влиянию витамина D на иммунный ответ организма. Как показывают исследования, витамин D способен ингибировать синтез провоспалительных цитокинов и, как следствие, играть важную роль в формировании иммунной толерантности, что важно при инфекционных, аутоиммунных заболеваниях и у пациентов после трансплантации органов. Витамин D может применяться как в качестве профилактики, так и в лечебных целях при инфекционных заболеваниях, в онкогематологии, аллергологии, гастроэнтерологии, а также способен влиять на внутриутробное развитие плода и иммунный ответ новорожденного, снижая риск развития патологии беременности, преждевременных родов и патологии плаценты, а также уменьшая частоту, степень тяжести и риск неблагоприятного исхода у новорожденных с врожденной и приобретенной инфекционной патологией. В постнатальном периоде нормальная обеспеченность витамином D не только снижает частоту, но и предотвращает формирование тяжелых форм аутоиммунных, аллергических заболеваний у детей и подростков.

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