Pediatrics. Consilium MedicumPediatrics. Consilium MedicumПедиатрия. Consilium Medicum2658-66302658-6622Consilium Medicum63418410.26442/26586630.2024.3.202896ArticlesСтатьиReview ArticleIron deficiency and its impact on post-vaccination immunity: a reviewДефицит железа и его влияние на поствакцинальный иммунитетhttps://orcid.org/0000-0002-0213-3304LebedevVyacheslav V.ЛебедевВячеслав Вячеславович
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук, врач-педиатр, аллерголог-иммунолог, зав. консультативно-диагностическим отд-нием Научно-клинического центра гематологии, онкологии и иммунологии

lebedev@hemacenter.orgDemikhovValery G.ДемиховВалерий Григорьевич
Russian Federation

D. Sci. (Med.), Prof.

д-р мед. наук, проф., Научно-клинический центр гематологии, онкологии и иммунологии

mlunyakova@mail.ruhttps://orcid.org/0000-0002-4543-2945LunyakovaMariya A.ЛуняковаМария Анатольевна
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук, врач-гематолог, педиатр, зав. отд. гематологии и онкологии Научно-клинического центра гематологии, онкологии и иммунологии

mlunyakova@mail.ruhttps://orcid.org/0000-0001-5404-4445DemikhovaElena V.ДемиховаЕлена Васильевна
Russian Federation

Head Department of Immunology and Immunoprophylaxis

зав. отд. иммунологии и иммунопрофилактики, врач-педиатр, аллерголог-иммунолог Научно-клинического центра гематологии, онкологии и иммунологии

demixev@yandex.ruhttps://orcid.org/0009-0008-5812-888XNosovaNatalia Y.НосоваНаталья Юрьевна
Russian Federation

Allergist-Immunologist

врач аллерголог-иммунолог отд. иммунологии и иммунопрофилактики Научно-клинического центра гематологии, онкологии и иммунологии

miss.natalino@yandex.ruPavlov Ryazan State Medical UniversityФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России0111202432542591007202410072024Copyright ©; 2024, Consilium MedicumCopyright ©; 2024, ООО "Консилиум Медикум"2024Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://pediatria.orscience.ru/2658-6630/article/view/634184

Modern vaccination programs are vital to overcoming the burden of infectious diseases and saving countless lives. The effective functioning of the adaptive immune system involves the interaction of many factors. Recent clinical studies have shown a significant role of iron in developing an immune response to infection and vaccination. Lymphocytes, the immune system's leading cells, cannot fully perform their functions without access to the circulating iron. The amount of iron bound to blood transferrin depends on its intake from food, and it is reduced during active inflammation due to the increase in the production of hepcidin, the main hormone regulating iron metabolism. Since iron deficiency conditions and chronic inflammatory processes are common, the potential impact of iron deficiency on the immune response warrants extensive study. The review presents data confirming the importance of iron for the correct functioning of the immune system and information on the effect of iron deficiency on the development of post-vaccination immunity.

Современные программы вакцинации имеют ключевое значение для преодоления бремени инфекционных болезней и спасения огромного числа человеческих жизней. Эффективная работа адаптивной иммунной системы обусловлена взаимодействием множества факторов. Клинические исследования, проведенные в последние годы, показали значимую роль железа в формировании иммунного ответа на инфекцию и вакцинацию. Лимфоциты, являясь ведущими клетками иммунной системы, не могут полноценно выполнять свои функции без доступа к циркулирующему железу. Количество железа, связанного с трансферрином крови, зависит от его поступления с пищей и снижается во время активного воспаления за счет увеличения выработки основного гормона, регулирующего обмен железа, – гепцидина. Поскольку железодефицитные состояния и хронические воспалительные процессы являются широко распространенными проблемами, вопрос потенциального влияния дефицита железа на иммунный ответ требует активного изучения. В обзоре представлены данные, подтверждающие важность железа для корректной работы иммунной системы, а также информация о влиянии дефицита железа на формирование поствакцинального иммунитета.

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