Pediatrics. Consilium MedicumPediatrics. Consilium MedicumПедиатрия. Consilium Medicum2658-66302658-6622Consilium Medicum63539510.26442/26586630.2024.2.202939ArticlesСтатьиReview ArticleDevelopment of the infant’s microbiota depending on the nature of feeding: A reviewФормирование микробиоты младенца в зависимости от характера вскармливанияhttps://orcid.org/0000-0003-4200-4598ZakharovaIrina N.ЗахароваИрина Николаевна
Russian Federation

D. Sci. (Med.), Prof.

д-р мед. наук, проф., зав. каф. педиатрии им. акад. Г.Н. Сперанского ФГБОУ ДПО РМАНПО, засл. врач РФ

zakharova-rmapo@yandex.ruhttps://orcid.org/0000-0002-2861-5619SugianNarine G.СугянНарине Григорьевна
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук, доц. каф. педиатрии им. акад. Г.Н. Сперанского ФГБОУ ДПО РМАНПО, зам. глав. врача ГБУЗ МО ХБ

zakharova-rmapo@yandex.ruhttps://orcid.org/0009-0005-2121-4010OrobinskayaYana V.ОробинскаяЯна Владимировна
Russian Federation

Graduate Student, Russian Medical Academy of Continuous Professional Education, Polyclinic “Mom and Baby” of Khimki Regional Hospital

аспирант каф. педиатрии им. акад. Г.Н. Сперанского ФГБОУ ДПО РМАНПО, поликлиника «Мама и малыш» ГБУЗ МО ХБ

zakharova-rmapo@yandex.ruRussian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииKhimki HospitalГБУЗ МО «Химкинская больница»24102024210611126082024Copyright ©; 2024, Consilium MedicumCopyright ©; 2024, ООО "Консилиум Медикум"2024Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://pediatria.orscience.ru/2658-6630/article/view/635395

Breast milk oligosaccharides (BMOs) are short polymers of simple sugars that are present in high concentrations in a woman’s breast milk (BM). Their content changes fast over time. Genetic factors, the duration of lactation, and environmental factors particularly influence the level of BMOs. BMOs can facilitate the development of the immune system and protect against infectious diseases directly through the interaction of intestinal epithelial cells or indirectly through the modulation of the intestinal microbiota, including stimulating Bifidobacterium growth. Clinical data suggest that adding BMOs to infant formula promotes normal neonatal growth and benefits infant health. Adding 1 or 2 BMOs to infant formulas is safe and brings their composition closer to the BM, allowing the child to develop harmoniously.

Олигосахариды грудного молока (ОГМ) представляют собой короткие полимеры простых сахаров, которые в высоких концентрациях присутствуют в ГМ женщины. Их содержание динамично меняется с течением времени. На уровень ОГМ особое влияние оказывают генетические факторы, а также имеют значение продолжительность лактации, особенности окружающей среды. ОГМ могут поддерживать развитие иммунной системы и обеспечивать защиту от инфекционных заболеваний непосредственно через взаимодействие эпителиальных клеток кишечника или косвенно через модуляцию кишечной микробиоты, включая стимуляцию роста Bifidobacterium. Клинические данные свидетельствуют о том, что добавление ОГМ в детские молочные смеси способствует нормальному росту новорожденного и приносит пользу его здоровью. Добавление 1 или 2 ОГМ в молочные смеси безопасно и приближает их состав к ГМ, позволяя ребенку гармонично развиваться.

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