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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatrics. Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Pediatrics. Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Педиатрия. Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2658-6630</issn><issn publication-format="electronic">2658-6622</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">635524</article-id><article-id pub-id-type="doi">10.26442/26586630.2024.3.202959</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Problematic issues of the impact of microplastics on the human body and the environment: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Осторожно – микропластик: влияние на организм человека и окружающую среду</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2181-8138</contrib-id><name-alternatives><name xml:lang="en"><surname>Pupykina</surname><given-names>Viktoria V.</given-names></name><name xml:lang="ru"><surname>Пупыкина</surname><given-names>Виктория Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант каф. педиатрии им. акад. Г.Н. Сперанского</p></bio><email>vika-pupykina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4200-4598</contrib-id><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>Ирина Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. педиатрии им. акад. Г.Н. Сперанского, засл. врач России</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-11-01" publication-format="electronic"><day>01</day><month>11</month><year>2024</year></pub-date><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>230</fpage><lpage>236</lpage><history><date date-type="received" iso-8601-date="2024-08-30"><day>30</day><month>08</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://pediatria.orscience.ru/2658-6630/article/view/635524">https://pediatria.orscience.ru/2658-6630/article/view/635524</self-uri><abstract xml:lang="en"><p>Currently, the widespread use of plastic has become a serious problem for the environment and human health. Microplastics, being an artificial polymer created by man, are highly resistant to external influences and their decomposition requires a significant amount of time. The article provides information on the distribution of microplastics and their impact on the environment and the human body, issues of detecting microplastics in the blood, heart, lungs, placenta and meconium, in breast milk, hypothetical mechanisms by which microplastics penetrate into human tissues and the metabolism of plasticizers in children with autism spectrum disorder and attention deficit hyperactivity disorder. In the modern world, plastic has become an integral part of our daily lives, the presence of microplastics in plastic bags for storing breast milk, in baby formula and polypropylene bottles has been demonstrated, the relationship between microplastics and postpartum depression, the relationship between fecal microplastics and the status of inflammatory bowel diseases has been described. Making the decision to limit the use of plastic products in your home is an important step that can play a key role in reducing environmental pollution and protecting the health of future generations.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время повсеместное распространение пластика стало серьезной проблемой не только для окружающей среды, но и для здоровья человека. Микропластик, являясь искусственным полимером, созданным человеком, отличается высокой устойчивостью к внешним воздействиям. Его разложение в почве требует значительного времени. В современном мире пластик стал неотъемлемой частью нашей повседневной жизни. Из микропластика, в частности, сделаны пакетики для хранения грудного молока, детские полипропиленовые бутылочки. В статье приведены сведения о влиянии данного вещества на организм человека. Микропластик обнаружен в крови, сердце, легких, плаценте, меконии младенца, грудном молоке. Выдвинуты гипотезы, объясняющие вероятные механизмы, с помощью которых микропластик проникает в ткани человека. В научной литературе обсуждается возможная связь пластификаторов с расстройством аутистического спектра, синдромом дефицита внимания и гиперактивности у детей. Описана возможная связь микропластика и послеродовой депрессии. Есть работы, доказывающие взаимосвязь между микропластиком и воспалительными заболеваниями кишечника. Принятие решения об ограничении использования пластиковых продуктов в быту является важным шагом, который может сыграть ключевую роль в уменьшении загрязнения окружающей среды и защите здоровья будущих поколений.</p></trans-abstract><kwd-group xml:lang="en"><kwd>environment</kwd><kwd>children</kwd><kwd>microplastics</kwd><kwd>impact on the human body</kwd><kwd>placenta</kwd><kwd>breast milk</kwd><kwd>autism</kwd><kwd>inflammatory bowel diseases</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>окружающая среда</kwd><kwd>дети</kwd><kwd>микропластик</kwd><kwd>влияние на организм человека</kwd><kwd>плацента</kwd><kwd>грудное молоко</kwd><kwd>аутизм</kwd><kwd>воспалительные заболевания кишечника</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Senathirajah K, Attwood S, Bhagwat G, et al. Estimation of the mass of microplastics ingested – A pivotal first step towards human health risk assessment. J Hazard Mater. 2021;404(Pt. B):124004. DOI:10.1016/j.jhazmat.2020.124004</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Омельченко Е.В., Киселева А.П. Микропластик в нашей жизни. Научные основы создания и реализации современных технологий здоровьесбережения. Материалы VI межрегиональной научно-практической конференции. Волгоград: Сфера, 2019;317-21 [Omelchenko EV, Kiseleva AP. Mikroplastik v nashei zhizni. Nauchnyie osnovy sozdaniia i realizatsii sovremennykh tekhnologii zdoroviesberezheniia. Materialy VI mezhregional'noi nauchno-prakticheskoi konferentsii. Volgograd: Sfera, 2019;317-21 (in Russian)].</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Ермачкова П.А., Кравченко А.Н., Залата О.А., Шибанов С.Э. Негативное влияние микропластика: системы-мишени организма человека. Мотивационные аспекты физической активности. Материалы V Всероссийской междисциплинарной конференции. Великий Новгород. 2021;23-8 [Ermachkova PA, Kravchenko AN, Zalata OA, Shibanov SE. Negativnoie vliianiie mikroplastika: sistemy-misheni organizma cheloveka. Motivatsionnyie aspekty fizicheskoi aktivnosti. Materialy V Vserossiiskoi mezhdistsiplinarnoi konferentsii. Velikii Novgorod. 2021;23-8 (in Russian)].</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Our Oceans: A Plastic Soup. 2011. Available at: https://news.climate.columbia.edu/2011/01/26/our-oceans-a-plastic-soup/ Accessed: 15.03.2024.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Gruber ES, Stadlbauer V, Pichler V, et al. To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity. Expo Health. 2023;15(1):33-51. DOI:10.1007/s12403-022-00470-8</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Difference Between Biomagnification and Bioaccumulation. 2023. Available at: https://www.geeksforgeeks.org/difference-between-biomagnification-and-bioaccumulation/ Accessed: 15.03.2024.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Peeken I, Primpke S, Beyer B, et al. Arctic sea ice is an important temporal sink and means of transport for microplastic. Nat Commun. 2018;9(1):1505. DOI:10.1038/s41467-018-03825-5</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Napper IE, Bede FR, Clifford H, et al. Reaching new heights in plastic pollution–preliminary findings of microplastics on Mount Everest. One Earth. 2020;3(5):621-30. DOI:10.1016/j.oneear.2020.10.020</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Cox KD, Covernton GA, Davies HL, et al. Human Consumption of Microplastics. Environ Sci Technol. 2019;53(12):7068-74. DOI:10.1021/acs.est.9b01517</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Plastic the hidden beautyngredient. 2022. Available at: https://www.beatthemicrobead.org/wp-content/uploads/2022/06/Plastic-TheHiddenBeautyIngredients.pdf. Accessed: 15.03.2024.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Stegmann P, Daioglou V, Londo M, et al. Plastic futures and their CO2 emissions. Nature. 2022;612(7939):272-6. DOI:10.1038/s41586-022-05422-5</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Tisler S, Christensen JH. Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water. J Hazard Mater. 2022;429:128331. DOI:10.1016/j.jhazmat.2022.128331</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Leslie HA, van Velzen MJM, Brandsma SH, et al. Discovery and quantification of plastic particle pollution in human blood. Environ Int. 2022;163:107199. DOI:10.1016/j.envint.2022.107199</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Yang Y, Xie E, Du Z, et al. Detection of Various Microplastics in Patients Undergoing Cardiac Surgery. Environ Sci Technol. 2023;57(30):10911-8. DOI:10.1021/acs.est.2c07179</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Jenner LC, Rotchell JM, Bennett RT, et al. Detection of microplastics in human lung tissue using μFTIR spectroscopy. Sci Total Environ. 2022;831:154907. DOI:10.1016/j.scitotenv.2022.154907</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Amato-Lourenço LF, Carvalho-Oliveira R, Júnior GR, et al. Presence of airborne microplastics in human lung tissue. J Hazard Mater. 2021;416:126124. DOI:10.1016/j.jhazmat.2021.126124</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>EcoReps Lunch &amp; Learn Workshop: Health Impacts of Particulate Contaminants and Microplastics. Available at: https://louisville.edu/sustainability/events/ecoreps-lunch-learn-workshop-health-impacts-of-particulate-contaminants-and-microplastics. Accessed: 15.03.2024.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Sripada K, Wierzbicka A, Abass K, et al. A Children’s Health Perspective on Nano- and Microplastics. Environ Health Perspect. 2022;130(1):15001. DOI:10.1289/EHP9086</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Ragusa A, Svelato A, Santacroce C, et al. Plasticenta: First evidence of microplastics in human placenta. Environ Int. 2021;146:106274. DOI:10.1016/j.envint.2020.106274</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Braun T, Ehrlich L, Henrich W, et al. Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics. 2021;13(7):921. DOI:10.3390/pharmaceutics13070921</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Ragusa A, Notarstefano V, Svelato A, et al. Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers (Basel). 2022;14(13):2700. DOI:10.3390/polym14132700</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Liu L, Zhang X, Jia P, et al. Release of microplastics from breastmilk storage bags and assessment of intake by infants: A preliminary study. Environ Pollut. 2023;323:121197. DOI:10.1016/j.envpol.2023.121197</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Zhang Q, Liu L, Jiang Y, et al. Microplastics in infant milk powder. Environ Pollut. 2023;323:121225. DOI:10.1016/j.envpol.2023.121225</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Li D, Shi Y, Yang L, et al. Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation. Nat Food. 2020;1(11):746-54. DOI:10.1038/s43016-020-00171-y</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Stein TP, Schluter MD, Steer RA, Ming X. Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders. PLoS One. 2023;18(9):e0289841. DOI:10.1371/journal.pone.0289841</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Jacobson MH, Hamra GB, Monk C, et al. Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression. JAMA Psychiatry. 2024;81(1):67-76. DOI:10.1001/jamapsychiatry.2023.3542</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Yan Z, Liu Y, Zhang T, et al. Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status. Environ Sci Technol. 2022;56(1):414-21. DOI:10.1021/acs.est.1c03924</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Seo MY, Moon S, Kim SH, Park MJ. Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017. Endocrinol Metab (Seoul). 2022;37(2):249-60. DOI:10.3803/EnM.2021.1235</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Zhang J, Wang L, Trasande L, et al. Occurrence of Polyethylene Terephthalate and Polycarbonate Microplastics in Infant and Adult Feces. Environment Sci Technol Lett. 2021;8(11):989-94. DOI:10.1021/acs.estlett.1c00559</mixed-citation></ref></ref-list></back></article>
