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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatrics. Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Pediatrics. Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Педиатрия. Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2658-6630</issn><issn publication-format="electronic">2658-6622</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">678078</article-id><article-id pub-id-type="doi">10.26442/26586630.2025.1.203216</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">History of the study of the composition and properties of human urine</article-title><trans-title-group xml:lang="ru"><trans-title>История изучения состава и свойств мочи человека</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4200-4598</contrib-id><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>Ирина Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, проф., зав. кафедры педиатрии им. акад. Г.Н. Сперанского, засл. врач РФ</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-0335-0704</contrib-id><name-alternatives><name xml:lang="en"><surname>Churilova</surname><given-names>Viktoriya D.</given-names></name><name xml:lang="ru"><surname>Чурилова</surname><given-names>Виктория Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Studentn</p></bio><bio xml:lang="ru"><p>аспирант кафедры педиатрии им. акад. Г.Н. Сперанского</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-04-04" publication-format="electronic"><day>04</day><month>04</month><year>2025</year></pub-date><volume>1</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>8</fpage><lpage>14</lpage><history><date date-type="received" iso-8601-date="2025-04-03"><day>03</day><month>04</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-04-03"><day>03</day><month>04</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://pediatria.orscience.ru/2658-6630/article/view/678078">https://pediatria.orscience.ru/2658-6630/article/view/678078</self-uri><abstract xml:lang="en"><p>The history of urine testing is deeply rooted in ancient times. Ancient civilizations mastered the art of urine testing by its appearance, and later, this test was deeply seated as an integral diagnostic method, as evidenced by numerous historical documents. Ancient knowledge, systematized and communicated through written sources, remains the basis for diagnosis and medical practice. Uroscopy, initially a visual-descriptive method, has been improved using modern technologies. To date, new opportunities for urine testing have become available, which has drastically changed clinical practice. The article presents the key takeaways of the history of studying the composition and properties of urine and also prospects for this diagnostic method.</p></abstract><trans-abstract xml:lang="ru"><p>История исследования мочи уходит глубоко корнями в архаичность. Представители древних цивилизаций овладели искусством анализа мочи по ее внешнему виду, и в дальнейшем данный анализ прочно укоренился в качестве неотъемлемого диагностического метода, о чем свидетельствуют многочисленные исторические документы. Древние знания, систематизированные и переданные через письменные источники, до сих пор служат основой для диагностики и лечебной практики. Уроскопия, будучи изначально визуально-описательным методом, усовершенствовалась с помощью современных технологий. К настоящему моменту открыты новые возможности для исследования мочи, что коренным образом изменило клиническую практику. В статье представлена квинтэссенция истории изучения состава и свойств мочи, также она дает представление о перспективах применения диагностического метода.</p></trans-abstract><kwd-group xml:lang="en"><kwd>historical review</kwd><kwd>urine analysis</kwd><kwd>microscopy</kwd><kwd>urinary sediment</kwd><kwd>uroscopy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>исторический обзор</kwd><kwd>анализ мочи</kwd><kwd>микроскопия</kwd><kwd>мочевой осадок</kwd><kwd>уроскопия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Utsch B, Klaus G. Urinalysis in children and adolescents. Dtsch Arztebl Int. 2014;111(37):617-25.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bush RB. Urine is an harlot, or a lier. JAMA. 1969;208(1):131-4.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Суботялов М.А., Сорокина Т.С., Дружинин В.Ю. Этапы развития аюрведической медицины. Проблемы социальной гигиены, здравоохранения и истории медицины. 2013;2 [Subotialov MA, Sorokina TS, Druzhinin VYu. Stages of development of Ayurvedic medicine. Problems of Social Hygiene, Health Care and History of Medicine. 2013;2 (in Russian)].</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Симонян Е.Э., Макулин А.В. Ведическая медицина. Научные исследования. 2016;10(11):96-100 [Simonian EE, Makulin A. Vedicheskaia meditsina. Nauchnye issledovaniia. 2016;10(11):96-100 (in Russian)].</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>A booklet to accompany an exhibition presented by the IBMS Historical Section Committee at the IBMS Biomedical Science Congress. History of Biomedical Science. From Matula to Mass Spectrometry. A History of Urine Tests in the Investigation of Human Disease. September 26-282005:1-44.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Sharma H, Chandola HM. Prameha in ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 1 – etiology, classification, and pathogenesis. J Alternative Complement Med. 2011;17(6):491-6.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Das S. Urology in ancient India. Indian J Urol. 2007;23(1):2-5.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Wellcome HS. The evolution of urine analysis: An historical sketch of the clinical examination of urine. Burroughs Wellcome. 1911.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Sanders LJ. From Thebes to Toronto and the 21st century: an incredible journey. Diabetes Spectrum. 2002;15(1):56.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Crnogorac-Jurcevic T. A brief history of urine examination – From ancient uroscopy to 21st century urinomics. Adv Biomarker Sci Technol. 2024;6:83-90.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Lines JG. A chronicle of the development of clinical chemistry. IFCC Newsletter. 1977;18: 3-9.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Dimopoulos C, Gialas A, Likourinas M, et al. Hippocrates: founder and pioneer of urology. Brit J Urol. 1980;52(2):73-4.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Eknoyan G. Looking at the urine: the renaissance of an unbroken tradition. Am J Kidney Dis. 2007;49(6):865-72.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Foster WD. Chemical pathology. In: A short history of clinical pathology. London: E and S Livingstone Ltd., 1961; p. 34-51.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Diskin ChJ. Surface tension, proteinuria, and the urine bubbles of Hippocrates. Lancet. 2000;355(9207):901-2.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Eknoyan G. The origins of nephrology–Galen, the founding father of experimental renal physiology. Am J Nephrol. 1989;9(1):66-82.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Armstrong JA. Urinalysis in Western culture: a brief history. Kidney Int. 2007;71(5):384-7.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Marketos SG, Diamandopoulos AA, Voyiatzakis E. Limits in the studies of the art of uroscopy: the Byzantine example. Am J Nephrol. 1994;14(3):239-45.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Kouba E, Wallen EM, Pruthi RS. Uroscopy by Hippocrates and Theophilus: prognosis versus diagnosis. J Urol. 2007;177(1):50-2.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Hanafy HM, Saad SM, El-Rifaie M, Al-Ghorab MM. Early arabian medicine Contribution to urology. Urology. 1976;8(1):63-7.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Angeletti LR, Gazzaniga V. Theophilus’ Auctoritas: the role of De urinis in the medical curriculum of the 12th–13th centuries. Am J Nephrol. 1999;19(2):165-71.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Pardalidis N. Uroscopy in Byzantium (330–1453 AD). J Urol. 2008;179(4):1271-6.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Connor H. Medieval uroscopy and its representation on misericords – part 1: uroscopy. Clin Med. 2001;1(6):507-9.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Eknoyan G. On the contributions of Paracelsus to nephrology. Nephrol Dial Transplant. 1996;11(7):1388-94.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Keele KD. The quest for significant physical signs. In: The evolution of clinical methods in medicine. Part II. London: Pitman Medical Publishing, 1961; p. 21-49.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Slater EA. Bright and Bright’s Disease. Res Medica. 1960;2(2).</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Захарова И.Н., Османов И.М., Мачнева Е.Б., и др. Клинический анализ мочи: историческое значение для развития медицины. Педиатрия. Consilium Medicum. 2019;1:83-8 [Zakharova IN, Osmanov IM, Machneva EB, et al. Clinical analysis of urine: historical significance for the development of medicine. Pediatrics. Consilium Medicum. 2019;1:83-8 (in Russian)].</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Fogazzi GB, Cameron JS. Urinary microscopy from the seventeenth century to the present day. Kidney Int. 1996;50(3):1058-68.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Johnson G. On the inflammatory diseases of the kidney. Med Chir Trans. 1847;30:164.2-191</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Addis T. Glomerular Nephritis, Diagnosis and Treatment. New York, MacMillan, 1948; p. 2.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Cameron JS. A history of urine microscopy. Clin Chem Lab Med. 2015;53 (Suppl. 2):s1453-64.</mixed-citation></ref></ref-list></back></article>
