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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatrics. Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Pediatrics. Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Педиатрия. Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2658-6630</issn><issn publication-format="electronic">2658-6622</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">71108</article-id><article-id pub-id-type="doi">10.26442/26586630.2021.1.200838</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Eosinophilic esophagitis: still a difficult condition to diagnose. Case report</article-title><trans-title-group xml:lang="ru"><trans-title>Эозинофильный эзофагит: все еще трудно и редко диагностируемое состояние. Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4200-4598</contrib-id><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>Ирина Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. педиатрии</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Osmanov</surname><given-names>Ismail M.</given-names></name><name xml:lang="ru"><surname>Османов</surname><given-names>Исмаил Магомедович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., глав. врач ГБУЗ</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pampura</surname><given-names>Aleksandr N.</given-names></name><name xml:lang="ru"><surname>Пампура</surname><given-names>Александр Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. педиатрии, рук. отд. аллергологии и клинической иммунологии НИКИ </p></bio><email>apampura1@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khomeriki</surname><given-names>Sergei G.</given-names></name><name xml:lang="ru"><surname>Хомерики</surname><given-names>Сергей Германович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. лаб. патоморфологии</p></bio><email>s.khomeriki@mknc.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vorobeva</surname><given-names>Aleksandra S.</given-names></name><name xml:lang="ru"><surname>Воробьева</surname><given-names>Александра Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, зав. 1-м педиатр. отд-нием</p></bio><email>dr.alexa@bk.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Goncharova</surname><given-names>Liudmila V.</given-names></name><name xml:lang="ru"><surname>Гончарова</surname><given-names>Людмила Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor</p></bio><bio xml:lang="ru"><p>врач 1-го педиатр. отд-ния</p></bio><email>doct-goncharova@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dmitrieva</surname><given-names>Diana K.</given-names></name><name xml:lang="ru"><surname>Дмитриева</surname><given-names>Диана Кирилловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Medical Resident</p></bio><bio xml:lang="ru"><p>ординатор 2-го года каф. поликлинической и неотложной педиатрии</p></bio><email>dmitrievadi@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Koshurnikova</surname><given-names>Anastasiia S.</given-names></name><name xml:lang="ru"><surname>Кошурникова</surname><given-names>Анастасия Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, зав. отд-нием эндоскопии</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kvirkvelia</surname><given-names>Merab A.</given-names></name><name xml:lang="ru"><surname>Квирквелия</surname><given-names>Мераб Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, врач-эндоскопист</p></bio><email>zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Simakova</surname><given-names>Mariia A.</given-names></name><name xml:lang="ru"><surname>Симакова</surname><given-names>Мария Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант каф. педиатрии</p></bio><email>simakova131@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sgibneva</surname><given-names>Aleksandra I.</given-names></name><name xml:lang="ru"><surname>Сгибнева</surname><given-names>Александра Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student</p></bio><bio xml:lang="ru"><p>студентка 6-го курса</p></bio><email>Asgibneva470@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Bashlyaeva Children’s City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Loginov Moscow Clinical Research Center</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Московский клинический научный центр им. А.С. Логинова» Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Morozov Children’s City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Морозовская детская городская клиническая больница» Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2021</year></pub-date><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>57</fpage><lpage>62</lpage><history><date date-type="received" iso-8601-date="2021-05-30"><day>30</day><month>05</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-05-30"><day>30</day><month>05</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://pediatria.orscience.ru/2658-6630/article/view/71108">https://pediatria.orscience.ru/2658-6630/article/view/71108</self-uri><abstract xml:lang="en"><p>The prevalence of eosinophilic esophagitis (EoE) has increased significantly over the past 20 years, which may be associated with an increase in awareness of the clinical features, the definition of criteria for the diagnosis of this condition. However, in our country, this disease remains rarely diagnosed. The difficulty in diagnosing EoE is due to the insufficiently high alertness of doctors regarding the detection of EoE, the peculiarities of differential diagnosis, and the need for invasive procedures. An important factor is the presence of a highly qualified pathologist on the staff to evaluate the obtained biopsy specimens. Further study of the pathogenesis of the disease, food triggers and the development of non-invasive methods for assessing the esophagus are required.</p></abstract><trans-abstract xml:lang="ru"><p>Частота диагностики эозинофильного эзофагита (ЭоЭ) значительно выросла в мире в течение последних 20 лет, что может быть связано с разными причинами, в том числе ростом осведомленности врачей о клинических особенностях ЭоЭ, выработкой критериев его диагностики. Однако в нашей стране ЭоЭ остается редко диагностируемым. Сложность диагностики обусловлена не только недостаточно высокой настороженностью врачей в отношении ЭоЭ, но и незнанием самого заболевания, а также отсутствием проведения биопсии при каждом эндоскопическом исследовании. Важным фактором остается наличие в штате больницы высококвалифицированного патоморфолога для правильной оценки получаемых биоптатов и точного подсчета количества эозинофилов. Требуются дальнейшее изучение патогенеза заболевания, пищевых триггеров и разработка новых малоинвазивных способов оценки состояния пищевода.</p></trans-abstract><kwd-group xml:lang="en"><kwd>esophagus</kwd><kwd>eosinophilic esophagitis</kwd><kwd>children</kwd><kwd>food allergy</kwd><kwd>malnutrition</kwd><kwd>clinical case</kwd><kwd>biopsy</kwd><kwd>histology</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>пищевод</kwd><kwd>эозинофильный эзофагит</kwd><kwd>дети</kwd><kwd>пищевая аллергия</kwd><kwd>недостаточность питания</kwd><kwd>клинический случай</kwd><kwd>биопсия</kwd><kwd>гистология</kwd><kwd>подсчет количества эозинофилов в биоптате</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Papadopoulou A, Koletzko S, Heuschkel R, et al, for the ESPGHAN. Eosinophilic Esophagitis Working Group and the Gastroenterology Committee. Management guidelines of eosinophilic esophagitis in childhood. J Pediatr Gastroenterol Nutr 2014; 58 (1): 107–18. DOI: 10.1097/MPG.0b013e3182a80be1</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014; 69 (8): 1008–25. DOI: 10.1111/all.12429</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Dellon ES, Hirano I. Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology 2018; 154 (2): 319–32.e3. DOI: 10.1053/j.gastro.2017.06.067</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Arias A, Perez-Martinez I, Tenias JM, Lucendo AJ. Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther 2016; 43: 3–15.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic esophagitis. N Engl J Med 2004; 351: 940–1.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Syed AA, Andrews CN, Shaffer E, et al. The rising incidence of eosinophilic oesophagitis is associated with increasing biopsy rates: a population-based study. Aliment Pharmacol Ther 2012; 36 (10): 950–8.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Giriens B, Yan P, Safroneeva E, et al. Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993–2013: A population-based study. Allergy 2015; 70: 1633–9.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Prasad GA, Alexander JA, Schleck CD, et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol 2009; 7: 1055–61.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Jensen ET, Kuhl JT, Martin LJ, et al. Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol 2018; 1412: 632–7e5.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Alexander ES, Martin LJ, Collins MH, et al. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol 2014; 134 (5): 1084–92e1.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Ishimura N, Shimura S, Jiao D, et al. Clinical features of eosinophilic esophagitis: differences between Asian and Western populations. J Gastroenterol Hepatol 2015; 30 (Suppl. 1): 71–7.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Bach JF. The hygiene hypothesis in autoimmunity: the role of pathogens and commensals. Nat Rev Immunol 2018; 18: 105–20.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol 2017; 18: 1076–83.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Spechler SJ. Speculation as to why the Frequency of Eosinophilic Esophagitis Is Increasing. Curr Gastroenterol Rep 2018; 20 (6): 26.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Cianferoni A, Ruffner MA, Guzek R, et al. Elevated expression of activated TH2 cells and milk-specific TH2 cells in milk-induced eosinophilic esophagitis. Ann Allergy Asthma Immunol 2018; 120 (2): 177–83e2.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>D’Alessandro A, Esposito D, Pesce M, et al. Eosinophilic esophagitis: from pathophysiology to treatment. World J Gastrointest Pathophysiol 2015; 6 (4): 150–8.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Doyle AD, Masuda MY, Kita H, Wright BL. Eosinophils in Eosinophilic Esophagitis: The Road to Fibrostenosis is Paved With Good Intentions. Front Immunol 2020; 11: 603295. DOI: 10.3389/fimmu.2020.603295</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Mohammad AA, Wu SZ, Ibrahim O, et al. Prevalence of atopic comorbidities in eosinophilic esophagitis: A case-control study of 449 patients. J Am Acad Dermatol 2017; 76 (3): 559–60. DOI: 10.1016/j.jaad.2016.08.068</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March. J Allergy Clin Immunol Pract 2018; 6 (5): 1528–33. DOI: 10.1016/j.jaip.2018.05.010</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Cianferoni A, Spergel JM, Muir A. Recent advances in the pathological understanding of eosinophilic esophagitis. Expert Rev Gastroenterol Hepatol 2015; 912: 1501–10.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Kottyan LC, Parameswaran S, Weirauch MT, et al. The genetic etiology of eosinophilic esophagitis. J Allergy Clin Immunol 2020; 145 (1): 9–15. DOI: 10.1016/j.jaci.2019.11.013</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Abonia JP, Blanchard C, Butz BB, et al. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010; 126: 140–9.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Spergel JM, Aceves SS, Kliewer K, et al. New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma &amp; Immunology Meeting. J Allergy Clin Immunol 2018; 142 (1): 48–53. DOI: 10.1016/j.jaci.2018.05.005</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Furuta GT, Katzka DA. Eosinophilic Esophagitis. N Engl J Med 2015; 373 (17): 1640–8. DOI: 10.1056/NEJMra1502863</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011; 128 (1): 3–20.e6; quiz 21-2. DOI: 10.1016/j.jaci.2011.02.040</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Bolton SM, Kagalwalla AF, Wechsler JB. Eosinophilic esophagitis in children: Endoscopic findings at diagnosis and post-intervention. Curr Gastroenterol Rep 2018; 20 (1): 4. DOI: 10.1007/s11894-018-0607-z</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Assa’ad AH, Putnam PE, Collins MH, et al. Pediatric patients with eosinophilic esophagitis: An 8-year follow-up. J Allergy Clin Immunol 2007; 119 (3): 731–8. DOI: 10.1016/j.jaci.2006.10.044</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Rubinstein E, Rosen RL. Respiratory symptoms associated with eosinophilic esophagitis. Pediatr Pulmonol 2018; 53 (11): 1587–91. DOI: 10.1002/ppul.24168</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Ruffner MA, Spergel JM. Pediatric eosinophilic esophagitis: Updates for the primary care setting. Curr Opin Pediatr 2018; 30 (6): 829–36. DOI: 10.1097/MOP.0000000000000698</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Lucendo AJ. Meta-analysis-based guidance for dietary management in eosinophilic esophagitis. Curr Gastroenterol Rep 2015; 17 (10): 464. DOI: 10.1007/s11894-015-0464-y</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Molina-Infante J, Bredenoord AJ, Cheng E, et al. PPI-REE Task Force of the European Society of Eosinophilic Oesophagitis (EUREOS). Proton pump inhibitor-responsive oesophageal eosinophilia: An entity challenging current diagnostic criteria for eosinophilic oesophagitis. Gut 2016; 65 (3): 524–31. DOI: 10.1136/gutjnl-2015-310991</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Aceves SS, Newbury RO, Chen D, et al. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy 2010; 65 (1): 109–16. DOI: 10.1111/j.1398-9995.2009.02142.x</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Borschel MW, Ziegler EE, Wedig RT, Oliver JS. Growth of healthy term infants fed an extensively hydrolyzed casein-based or free amino acid-based infant formula: a randomized, double-blind, controlled trial. Clin Pediatr 2013; 52 (10): 910–7.</mixed-citation></ref></ref-list></back></article>
