Sleep disorders in children with rheumatic diseases

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Abstract

Rheumatic diseases (RD) are often diagnosed in childhood. Sleep disorders are commonly associated with RD in children. It is stressed that sleep disorders found in this type of clinical pathology cannot be exceptionally considered as an epiphenomenon typical to any form of chronic disease; rather, sleep disorders should be regarded as a part of the clinical manifestations of RD. An important role in the origins of this association is played by specific inflammatory mediators involved in the pathogenesis of various RD, which simultaneously affect the structure of sleep and contribute to sleep disorders. There are both nonspecific and characteristic variants of sleep disorders detected in some leading clinical forms of RD in children, in particular in juvenile rheumatoid (idiopathic) arthritis, systemic lupus erythematosus, systemic scleroderma, seronegative spondyloarthropathies, fibromyalgia. There is a relationship between the severity of sleep disorders, the activity of RD, the degree of emotional disorders and pain symptoms in children. Approaches to the correction of sleep disorders in children in the context of the treatment of RD are substantiated.

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About the authors

Igor A. Kelmanson

Almazov National Medical Research Centre; Saint Petersburg State Institute of Psychology and Social Work

Author for correspondence.
Email: iakelmanson@hotmail.com
ORCID iD: 0000-0002-4449-2786

D. Sci. (Med.), Prof., Almazov National Medical Research Centre, Saint Petersburg State Institute of Psychology and Social Work

Russian Federation, Saint Petersburg; Saint Petersburg

References

  1. Knaack L, Janicki J. Rheumatologische Erkrankungen und Schlaf-Schlafmedizinische Aspekte der Diagnostik und Therapie-Eine literaturbasierte Übersicht. Laryngo-Rhino-Otologie. 2019;98(11):776-88.
  2. Opp MR. Cytokines and sleep. Sleep Med Rev. 2005;9(5):355-64.
  3. Imeri L, Opp MR. How (and why) the immune system makes us sleep. Nat Rev Neurosci. 2009;10(3):199-210.
  4. Weinberger JF, Raison CL, Rye DB, et al. Inhibition of tumor necrosis factor improves sleep continuity in patients with treatment resistant depression and high inflammation. Brain Behav Immun. 2015;47:193-200.
  5. Collado-Hidalgo A, Bower JE, Ganz PA, et al. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin Cancer Res. 2006;12(9):2759-66.
  6. Louati K, Berenbaum F. Fatigue in chronic inflammation – a link to pain pathways. Arthritis Res Ther. 2015;17:254.
  7. Davis CJ, Krueger JM. Sleep and cytokines. Sleep Med Clin. 2012;7(3):517-27.
  8. Schäfers M, Sommer C, Geis C, et al. Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro. Neuroscience. 2008;157(2):414-23.
  9. Khairova RA, Machado-Vieira R, Du J, Manji HK. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol. 2009;12(4):561-78.
  10. Aletaha D, Landewe R, Karonitsch T, et al. Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Arthritis Care Res. 2008;59(10):1371-7.
  11. Iaboni A, Gladman DD, Urowitz MB, Moldofsky H. Disordered sleep, sleepiness and depression in chronically tired patients with Systemic Lupus Erythematosis (SLE). Sleep. 2004;27:327-8.
  12. Valencia‐Flores M, Resendiz M, Castãno VA, et al. Objective and subjective sleep disturbances in patients with systemic lupus erythematosus. Arthritis Rheum. 1999;42(10):2189-93.
  13. Finan PH, Goodin BR, Smith MT. The association of sleep and pain: an update and a path forward. J Pain. 2013;14(12):1539-52.
  14. Irwin MR, Olmstead R, Carrillo C, et al. Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis. Sleep. 2012;35(4):537-43.
  15. Valrie CR, Bromberg MH, Palermo T, Schanberg LE. A systematic review of sleep in pediatric pain populations. JDBP. 2013;34(2):120.
  16. Lentz MJ, Landis CA, Rothermel J, Shaver JL. Effects of selective slow wave sleep disruption on musculoskeletal pain and fatigue in middle aged women. J Rheumatol. 1999;26(7):1586-92.
  17. Onen SH, Alloui A, Gross A, et al. The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res. 2001;10(1):35-42.
  18. Winfield JB. Psychological determinants of fibromyalgia and related syndromes. Curr Rev Pain. 2000;4(4):276-86.
  19. Cakirbay H, Bilici M, Kavakci Ö, et al. Sleep quality and immune functions in rheumatoid arthritis patients with and without major depression. Int J Neurosci. 2004;114(2):245-56.
  20. Steiger A. Neurochemical regulation of sleep. J Psychiatr Res. 2007;41(7):537-52.
  21. Neeck G, Federlin K, Graef V, et al. Adrenal secretion of cortisol in patients with rheumatoid arthritis. J Rheumatol. 1990;17(1):24-9.
  22. Crofford LJ, Kalogeras KT, Mastorakos G, et al. Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab. 1997;82(4):1279-83.
  23. Mastorakos G, Ilias I. Relationship between interleukin-6 (IL-6) and hypothalamic-pituitary-adrenal axis hormones in rheumatoid arthritis. Z Rheumatol. 2000;59(2):II75-II9.
  24. Meyer-Hermann M, Figge MT, Straub RH. Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach. Arthritis Rheum. 2009;60(9):2585-94.
  25. Krueger JM. The role of cytokines in sleep regulation. Curr Pharm Des. 2008;14(32):3408-16.
  26. Kouri VP, Olkkonen J, Kaivosoja E, et al. Circadian timekeeping is disturbed in rheumatoid arthritis at molecular level. PLoS one. 2013;8(1):e54049.
  27. Rao RT, Pierre KK, Schlesinger N, Androulakis IP. The potential of circadian realignment in rheumatoid arthritis. Crit Rev Biomed Eng. 2016;44(3):177-91.
  28. Irwin MR, Carrillo C, Olmstead R. Sleep loss activates cellular markers of inflammation: sex differences. Brain Behav Immun. 2010;24(1):54-7.
  29. Opp MR, Krueger JM. Sleep and Host Defense. In: Principles and practice of sleep medicine. Eds MH Kryger, T Roth, WC Dement. 6th ed. Philadelphia, PA: Elsevier, 2017; p. 193-201.
  30. Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016;80(1):40-52.
  31. Irwin MR, Wang M, Campomayor CO, et al. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 2006;166(16):1756-62.
  32. Irwin MR. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015;66:143-72.
  33. Goes ACJ, Reis LAB, Silva MBG, et al. Rheumatoid arthritis and sleep quality. Rev Bras Reumatol Engl Ed. 2017;57(4):294-8.
  34. Abad VC, Sarinas PSA, Guilleminault C. Sleep and rheumatologic disorders. Sleep Med Rev. 2008;12(3):211-28.
  35. Løppenthin K, Esbensen BA, Jennum P, et al. Sleep quality and correlates of poor sleep in patients with rheumatoid arthritis. Clin Rheumatol. 2015;34(12):2029-39.
  36. Bjurstrom MF, Olmstead R, Irwin MR. Reciprocal relationship between sleep macrostructure and evening and morning cellular inflammation in rheumatoid arthritis. Psychosom Med. 2017;79(1):24-33.
  37. Cairns AP, McVeigh JG. A systematic review of the effects of dynamic exercise in rheumatoid arthritis. Rheumatol Int. 2009;30(2):147-58.
  38. Wolfe F, Michaud K, Li T. Sleep disturbance in patients with rheumatoid arthritis: evaluation by medical outcomes study and visual analog sleep scales. J Rheumatol. 2006;33(10):1942-51.
  39. Drewes AM, Svendsen L, Taagholt SJ, et al. Sleep in rheumatoid arthritis: a comparison with healthy subjects and studies of sleep/wake interactions. Br J Rheumatol. 1998;37(1):71-81.
  40. Bloom BJ, Owens JA, McGuinn M, et al. Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritis. J Rheumatol. 2002;29(1):169-73.
  41. Lopes MC, Guilleminault C, Rosa A, et al. Delta sleep instability in children with chronic arthritis. Braz J Med Biol Res. 2008;41(10):938-43.
  42. Shyen S, Amine B, Rostom S, et al. Sleep and its relationship to pain, dysfunction, and disease activity in juvenile idiopathic arthritis. Clin Rheumatol. 2014;33(10):1425-31.
  43. Twilt M, Schulten AJM, Nicolaas P, et al. Facioskeletal changes in children with juvenile idiopathic arthritis. Ann Rheum Dis. 2006;65(6):823-5.
  44. Zamir G, Press J, Tal A, Tarasiuk A. Sleep fragmentation in children with juvenile rheumatoid arthritis. J Rheumatol. 1998;25(6):1191-7.
  45. May KP, West SG, Baker MR, Everett DW. Sleep apnea in male patients with the fibromyalgia syndrome. Am J Med. 1993;94(5):505-8.
  46. Shen TC, Hang LW, Liang SJ, et al. Risk of obstructive sleep apnoea in patients with rheumatoid arthritis: a nationwide population-based retrospective cohort study. BMJ Open. 2016;6(11):e013151.
  47. Alamoudi O. Sleep-disordered breathing in patients with acquired retrognathia secondary to rheumatoid arthritis. Med Sci Monit. 2006;12(12):CR530-534.
  48. Shoda N, Seichi A, Takeshita K, et al. Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features. Eur Spine J. 2009;18(6):905-10.
  49. Taylor-Gjevre RM, Gjevre JA, Skomro R, Nair B. Restless legs syndrome in a rheumatoid arthritis patient cohort. J Clin Rheumatol. 2009;15(1):12-5.
  50. Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance. Sleep Med. 2014;15(8):860-73.
  51. Hultgren S, Broman J-E, Gudbjörnsson B, et al. Sleep disturbances in outpatients with ankylosing spondylitis – a questionnaire study with gender implications. Scand J Rheumatol. 2000;29(6):365-9.
  52. Jones SD, Koh WH, Steiner A, et al. Fatigue in ankylosing spondylitis: its prevalence and relationship to disease activity, sleep, and other factors. J Rheumatol. 1996;23(3):487-90.
  53. Défalque RJ, Hyder ML. Laryngeal mask airway in severe cervical ankylosis. Can J Anaesth. 1997;44(3):305-7.
  54. Ortancil O, Sarikaya S, Sapmaz P, et al. The effect(s) of a six-week home-based exercise program on the respiratory muscle and functional status in ankylosing spondylitis. J Clin Rheumatol. 2009;15(2):68-70.
  55. Tench CM, McCurdie I, White PD, d'Cruz DP. The prevalence and associations of fatigue in systemic lupus erythematosus. Rheumatology. 2000;39(11):1249-54.
  56. Krupp LB, LaRocca NG, Muir J, Steinberg AD. A study of fatigue in systemic lupus erythematosus. J Rheumatol. 1990;17(11):1450-2.
  57. Palma BD, Tufik S. Increased disease activity is associated with altered sleep architecture in an experimental model of systemic lupus erythematosus. Sleep. 2010;33(9):1244-8.
  58. Prado GF, Allen RP, Trevisani VMF, et al. Sleep disruption in systemic sclerosis (scleroderma) patients: clinical and polysomnographic findings. Sleep Med. 2002;3(4):341-5.
  59. Yunus MB. A comprehensive medical evaluation of patients with fibromyalgia syndrome. Rheum Dis Clin North Am. 2002;28(2):201-17.
  60. Buskila D, Cohen H. Comorbidity of fibromyalgia and psychiatric disorders. Curr Pain Headache Rep. 2007;11(5):333-8.
  61. Ablin JN, Buskila D. Predicting fibromyalgia, a narrative review: Are we better than fools and children? Eur J Pain. 2014;18(8):1060-6.
  62. Stehlik R, Arvidsson L, Ulfberg J. Restless legs syndrome is common among female patients with fibromyalgia. Eur Neurol. 2009;61(2):107-11.
  63. Branco J, Atalaia A, Paiva T. Sleep cycles and alpha-delta sleep in fibromyalgia syndrome. J Rheumatol. 1994;21(6):1113-7.
  64. Davies S, Crawley E. Chronic fatigue syndrome in children aged 11 years old and younger. Arch Dis Child. 2008;93(5):419-21.
  65. Drewes AM, Nielsen KD, Taagholt SJ, et al. Sleep intensity in fibromyalgia: focus on the microstructure of the sleep process. Rheumatology. 1995;34(7):629-35.
  66. Palermo TM, Kiska R. Subjective sleep disturbances in adolescents with chronic pain: relationship to daily functioning and quality of life. J Pain. 2005;6(3):201-7.
  67. Olsen MN, Sherry DD, Boyne K, et al. Relationship between sleep and pain in adolescents with juvenile primary fibromyalgia syndrome. Sleep. 2013;36(4):509-16.
  68. Taylor-Gjevre RM, Gjevre JA, Nair BV, et al. Improved sleep efficiency after anti-tumor necrosis factor alpha therapy in rheumatoid arthritis patients. Ther Adv Musculoskelet Dis. 2011;3(5):227-33.
  69. Yount S, Sorensen MV, Cella D, et al. Adalimumab plus methotrexate or standard therapy is more effective than methotrexate or standard therapies alone in the treatment of fatigue in patients with active, inadequately treated rheumatoid arthritis. Clin Exp Rheumatol. 2007;25(6):838.
  70. Zamarron C, Maceiras F, Mera A, Gomez-Reino JJ. Effect of the first infliximab infusion on sleep and alertness in patients with active rheumatoid arthritis. Ann Rheum Dis. 2004;63(1):88-90.
  71. Fragiadaki K, Tektonidou MG, Konsta M, et al. Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis. J Rheumatol. 2012;39(1):60-2.
  72. Genovese MC, Schiff M, Luggen M, et al. Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy. Ann Rheum Dis. 2008;67(4):547-54.
  73. Кельмансон И.А. Сон ребенка в онтогенезе и использование стандартизованного опросника для оценки поведения детей во время сна. Рос. вестн. перинатологии и педиатрии. 2017;62(3):37-52 [Kelmanson IA. Child sleep ontogeny and use of standardised questionnaire for evaluation of child sleep behavior. Ros. vestn. perinatologii i pediatrii. 2017;62(3):37-52 (in Russian)].
  74. McKenna SG, Donnelly AE, Esbensen BA, et al. The impact of exercise on sleep (time, quality, and disturbance) in patients with rheumatoid arthritis: a study protocol for a pilot randomised controlled trial. Rheumatol Int. 2018;38(7):1191-8.
  75. Кельмансон И.А. Фармакотерапия расстройств сна в дошкольном и младшем школьном возрасте. Журн. неврологии и психиатрии им. C.C. Корсакова. 2020;120(9-2):55-61 [Kelmanson IA. Pharmacotherapy of sleep disorders in pre-school and elemenrary school age. Zhurnal nevrologii I psikhiatrii named after SS Korsakov. 2020;120(9-2):55-61 (in Russian)].
  76. Полуэктов М.Г. Применение психотропных препаратов при хронической инсомнии в клинической практике. Журн. неврологии и психиатрии им. С.С. Корсакова. 2021;121(4-2):61-7. [Poluektov MG. Use of phychotropic medications in chronic insomnia in clinical practice. Zhurnal nevrologii I psikhiatrii named after SS Korsakov. 2021;121(4-2):61-7 (in Russian)].
  77. Vogelzangs N, Beekman AT, van Reedt Dortland AK, et al. Inflammatory and metabolic dysregulation and the 2-year course of depressive disorders in antidepressant users. Neuropsychopharmacology. 2014;39(7):1624-34.
  78. Hardeland R. Melatonin and inflammation – Story of a double-edged blade. J Pineal Res. 2018;65(4):e12525.
  79. Sanchez A, Calpena AC, Clares B. Evaluating the oxidative stress in inflammation: role of melatonin. Int J Mol Sci. 2015;16(8):16981-7004.
  80. Maestroni GJM, Sulli A, Pizzorni C, et al. Melatonin in rheumatoid arthritis: synovial macrophages show melatonin receptors. Ann N Y Acad Sci. 2002;966(1):271-5.
  81. Andersen LPH, Gögenur I, Rosenberg J, Reiter RJ. The safety of melatonin in humans. Clin Drug Investig. 2016;36(3):169-75.
  82. Siegel DM, Janeway D, Baum J. Fibromyalgia syndrome in children and adolescents: clinical features at presentation and status at follow-up. Pediatrics. 1998;101(3):377-82.

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