Selective IgA deficiency is the most common primary immunodeficiency disorder. Most patients with IgA deficiency are asymptomatic, other patients can develop recurrent infectious, allergic and autoimmune diseases. Early detection of selective IgA deficiency can determine the pathogenetic reasoning of frequent infectious and refractory course of atopic diseases, contribute to the timely correct diagnosis of disorders associated with the primary immunodeficiency, and also prevent the development of severe anaphylactic reactions to blood transfusion. The article provides data on IgA structure and functions, determines the pathogenetic mechanisms of its deficiency, and analyzes the clinical manifestations of the disease. A literature review is complemented by a discussion of two clinical cases demonstrating the importance of timely diagnosis of IgA deficiency.
Key words: children, primary immunodeficiency disorders, immunoglobulin A, selective IgA deficiency, atopic diseases, respiratory infections, intestinal infections, autoimmune pathology, celiac disease, microbiota.
About the Author
1 Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2 Dmitriy Rogachev National Medical Research Center for Pediatric Hematology, Oncology and Immunology,
3 Baslyaeva Children's City Clinical Hospital, Moscow, Russia
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For citation:Dmitrieva Iu.A., Zakharova I.N., Radchenko E.R. Selective IgA deficiency in pediatrician practice. Pediatrics. Consilium Medicum. 2019; 3: 122–126. DOI: 10.26442/26586630.2019.3.190633Founder:
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