Synthesis of Reactive Pegylated Indocyanine Dyes

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Abstract

Synthesis was carried out with the selection of conditions for the isolation and purification of fluorescently labeled polyethylene glycol with a reactive carboxyl group for labeling biomolecules. Pegylated nucleotides, which are part of drugs, allow targeted delivery to the target organ, prolong the half-life, reduce immunogenicity and increase stability.

About the authors

V. E Shershov

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

V. E Kuznetsova

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: kuzneimb@gmail.com
Moscow, Russia

G. F Shtylev

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

I. Yu Shishkin

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

R. A Miftahov

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

V. I Butvilovskaya

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

I. V Grechishnikova

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

A. A Stomahin

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

O. A Zasedateleva

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

A. V Chudinov

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Moscow, Russia

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