3-bromomethyl-5,7-dimethyl-2-oxaadamantan-1-ol in nucleophilic substitution reactions

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Abstract

The synthesis was carried out and the transformations of 1-aryladamantanes in fuming nitric acid were studied. The reactions include nitroxylation of saturated cage and nitration of the aromatic moiety and lead to 3-(dinitroaryl)-1-adamantylnitrates. A number of new polyfunctional compounds have been synthesized based on reactions of substituted 3-(dinitroaryl)-1-adamantyl nitrates with nucleophiles in concentrated sulfuric acid. Due to the multifunctionality, the obtained compounds can be used as starting materials in the synthesis of substances with a wide spectrum of biological activity and materials with a complex of valuable properties.

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E. A. Ivleva

Samara State Technical University

Author for correspondence.
Email: ivleva.ea@samgtu.ru
ORCID iD: 0000-0001-5778-860X
Russian Federation, ul. Molodogvardeiskaya, 244, Samara, 443100

Yu. E. Khatmullina

Samara State Technical University

Email: ivleva.ea@samgtu.ru
Russian Federation, ul. Molodogvardeiskaya, 244, Samara, 443100

M. S. Zaborskaya

Samara State Technical University

Email: ivleva.ea@samgtu.ru
Russian Federation, ul. Molodogvardeiskaya, 244, Samara, 443100

E. V. Simatova

Samara State Technical University

Email: ivleva.ea@samgtu.ru
Russian Federation, ul. Molodogvardeiskaya, 244, Samara, 443100

D. A. Bazarova

Samara State Technical University

Email: ivleva.ea@samgtu.ru
Russian Federation, ul. Molodogvardeiskaya, 244, Samara, 443100

Yu. N. Klimochkin

Samara State Technical University

Email: ivleva.ea@samgtu.ru
ORCID iD: 0000-0002-7335-4040
Russian Federation, ul. Molodogvardeiskaya, 244, Samara, 443100

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