Synthesis Evaluation of Antibacterial Activity of New Derivatives of 1,3-Diaza-2-phenylamino-, 7-Amino-1,3,5-triaza-, 7-Carbamoylphenylamino-1,3,5-triazadamantanes

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Abstract

A number of new derivatives of diaza- and triazadamantanes were synthesized and their antibacterial activity was studied by the interaction of 2-(4-aminophenyl)-5,7-disubstituted-1,3-diazadamantanes, 1,3,5-triazadamantan-7-amine and 1,3,5-triazadamantan-7-yl-(aminophenyl)methanones with anhydrides of substituted succinic and glutaric acids. Among the synthesized compounds, some possess moderate activity, suppressing the growth of gram-positive and gram-negative microorganisms in a zone with a diameter of d = 14–16 mm.

About the authors

K. A Gevorkyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ORCID iD: 0000-0003-3604-6038
Yerevan, Armenia

M. V Galstyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ORCID iD: 0000-0002-9475-8810
Yerevan, Armenia

M. V Aleksanyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: amv196087@mail.ru
ORCID iD: 0009-0004-1722-9140
Yerevan, Armenia

J. A Avakimyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ORCID iD: 0000-0002-8470-5176
Yerevan, Armenia

H. M Stepanyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ORCID iD: 0000-0001-7236-5947
Yerevan, Armenia

R. Y Muradyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ORCID iD: 0000-0002-4110-9454
Yerevan, Armenia

A. D Harutyunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ORCID iD: 0000-0002-8320-0942
Yerevan, Armenia

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