Post-covid syndrome in children in rare cases of COVID-19

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Post-covid syndrome (PCS) is a symptom complex that occurs during and after COVID-19 lasting more than 12 weeks, which is not a possible disease. The clinical manifestations of PCS are many-sided, under their mask or manifestations or exacerbations of chronic organic activity, the trigger of which was the virus, are hidden. PCS is a diagnosis of exclusion. The main manifestations of PCS: autonomic dysregulation, cognitive and psycho-emotional disorders, disorders of the respiratory system, cardiovascular, digestive systems. Direct pathogenic factors, the main neurological manifestations are PCS of preservation of brain hypoperfusion, hypoxia and hypoxemia, resulting in energy deficiency of neuronal structures, violation of the probable, as well as virus-induced structural detection of neurons in the cortex and subcortical structures of the brain. The severity and duration of exposure appear to be increasingly dependent on the body's response to SARS-CoV-2. PCS has a different severity of severity in recovered patients and does not always depend on the severity of the acute period. Timely examination with differential diagnosis allows not only to make a diagnosis, but also to recommend therapy with a personalized approach to the correction of PCS.

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Irina N. Zakharova

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
ORCID iD: 0000-0003-4200-4598

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Ismail M. Osmanov

Bashlyaeva Children's City Clinical Hospital; Pirogov Russian National Research Medical University

ORCID iD: 0000-0003-3181-9601

D. Sci. (Med.), Prof., Bashlyaeva Children's City Clinical Hospital

Russian Federation, Moscow; Moscow

Tatiana M. Tvorogova

Russian Medical Academy of Continuous Professional Education

ORCID iD: 0000-0001-5249-1452

Cand. Sci. (Med.)

Russian Federation, Moscow

Irina V. Berezhnaya

Russian Medical Academy of Continuous Professional Education

ORCID iD: 0000-0002-2847-6268

Cand. Sci. (Med.)

Russian Federation, Moscow

Anastasia V. Makhaeva

Russian Medical Academy of Continuous Professional Education


Graduate Student

Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. The most common symptoms of post-COVID syndrome (PCS) in adults (adapted from [3]).

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2. Fig. 2. Long-term health effects of COVID-19 in individuals with symptoms of a PCR test without severe manifestations of disease, depending on the age of the patient (adaptation [10]).

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3. Fig. 3. Symptoms of the “state after COVID-19” in adults according to publications [12].

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4. Fig. 4. Clinical symptoms in children with PCS of the British SARS-CoV-2 virus [17].

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5. Fig. 5. Neurological symptoms in children with PCS of the British SARS-CoV-2 virus [17].

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6. Fig. 6. Polysystem nature of somatoform societies in conditions of autonomic dysregulation in post-covid asthenia.

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