Assessment of the state of compensatory resources and the degree of adaptation of the body to environmental conditions in full-term infants: cross-sectional study

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Abstract

Aim. Assessment of the state of compensatory resources and the degree of adaptation of the body to environmental conditions in early and full-term infants in comparison with each other and with practically healthy children.

Materials and methods. Under the supervision of 135 infants. 110 were born from mothers with a burdened somatic and obstetric-gynecological history, 41 of them were born at 37–38 weeks (Group 1), 69 at 39–42 weeks (Group 2). The control group (Group 3) consisted of 25 practically healthy children born to practically healthy mothers as a result of physiological pregnancies and childbirth at 38–40 weeks. The children were examined in dynamics at the age of 1 (n=126), 3 (n=116), 6 (n=110), 12 (n=111) months. A comprehensive analysis of the data of anamnesis, physical examination, cardiointervalography was carried out. The following parameters were evaluated initially and in response to the tilt test: mode (М0), mode amplitude (AM0), delta x (∆Х), voltage index (IN). Nonparametric methods of statistical analysis were used.

Results. At the age of 2 to 3 days infants born to women with a history of poor health recorded a significant decrease in the median IN1 value, respectively, in Groups 1, 2, and 3, which indicates a decrease in compensatory reserves, particularly in neonates born at 38–40 weeks. At 1 month of age, Group 1 and 2 had higher median IN1 values of 804 and 746 versus 550 in Group 3, indicating the development of compensatory resource tension, particularly in children born at 37–38 weeks. At 3 months of age, children in group 1 retained a compensatory tension of IN1 resources – 521 versus 468 and 460 in groups 2 and 3. At 6 months of age, there is a slight decrease in compensatory IN1 reservers at 6 months of age in children from women with a history of a history of a history of a history of a disease – 376 and 357 versus 400 in Group 3. At 12 months of age, children in the main groups have even more decreased compensatory resources, especially in group 1 IN1 – 206, 284 and 380 respectively in groups 1, 2 and 3.

Conclusion. The decrease of functional reserve of adaptation in children of groups 1st and 2nd was facilitated by the influence burdened with somatic and obstetric-gynecological history of mothers, regardless of gestational age and subsequently the health characteristics of children themselves. The statistically significant differences found in the state of compensatory resources and the degree of adaptation of the organism to environmental conditions justify the personalized approach, which justifies a personalized approach when choosing rehabilitation measures.

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About the authors

Vitaly V. Derevtsov

Semashko Children's Center for Diagnosis and Treatment

Email: VitalyDerevtsov@gmail.com
ORCID iD: 0000-0002-8819-7033

D. Sci. (Med.)

Russian Federation, Moscow

Evgeniy V. Neudakhin

Voino-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children

Email: pediatr_ev@mail.ru
ORCID iD: 0000-0002-9124-1306

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Liudmila K. Antonova

Tver State Medical University

Email: antonova.lk@yandex.ru
ORCID iD: 0000-0002-5587-5969

D. Sci. (Med.), Prof.

Russian Federation, Tver

Fedor P. Romanyuk

Mechnikov North-Western State Medical University

Email: fedor.romanyk@spbmapo.ru
ORCID iD: 0000-0001-8577-2330

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Dmitry O. Ivanov

Saint Petersburg State Pediatric Medical University

Email: doivanov@yandex.ru
ORCID iD: 0000-0002-0060-4168

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Lyudmila V. Kozlova

Smolensk Regional Children's Clinical Hospital

Email: milkozlova@yandex.ru
ORCID iD: 0000-0003-0625-2877

D. Sci. (Med.), Prof.

Russian Federation, Smolensk

Vladimir V. Bekezin

Smolensk State Medical University

Author for correspondence.
Email: smolenskbvv@yandex.ru
ORCID iD: 0000-0001-9141-5348

D. Sci. (Med.), Prof.

Russian Federation, Smolensk

Galina N. Chumakova

Saint Petersburg State Pediatric Medical University

Email: zelchum-neo@yandex.ru
ORCID iD: 0000-0001-5353-4610

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Guzel N. Chistyakova

Ural Research Institute for Maternal and Infant Health

Email: chistyakovagn@niiomm.ru
ORCID iD: 0000-0002-0852-6766

D. Sci. (Med.), Prof.

Russian Federation, Ekaterinburg

Marina Yu. Shcherbakova

People’s Friendship University of Russia (RUDN University)

Email: shcherbakova732@gmail.com
ORCID iD: 0000-0001-6705-8707

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Anastasia V. Derevtsova

Smolensk State Medical University

Email: nastyaderevtsova@gmail.com
ORCID iD: 0000-0002-9015-1050

Student

Russian Federation, Smolensk

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Supplementary files

Supplementary Files
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1. Fig. 1. Сardiointervalogram.

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2. Fig. 2. Diagram of the span of the stress index initially (IN1) in samples of children.

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3. Fig. 3. Comparative characteristics of relative frequencies (%) with 95% CI for adaptive reactions in samples of children.

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