Resolution of the Council of Experts “Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics”

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Abstract

The appearance of new high-tech microbiological research methods has significantly changed the understanding of the human microbiome. The purpose of the meeting of the Council of Experts “Dysbiosis. The immediate and long-term consequences of microbiome disorders and options for their correction with probiotics” was the definition of modern positions about possible methods of studying the intestinal microbiome, the possibilities of correcting dysbiosis, the use of Saccharomyces boulardii CNCM I-745 to correct microbiome disorders in various clinical situations. The criteria of the microbiological “norm” for the intestinal microbiome have not been definitively established. To study the microbiome, a set of methods is used that combine cultural and molecular genetic methods that complement each other. Currently, there are no clinical markers of dysbiosis, and laboratory markers of dysbiosis require modification.

Probiotics can provide restoration of the intestinal microbiota. The effectiveness and safety of the use of Saccharomyces boulardii CNCM I-745 for this purpose has been proven. In the case of acute intestinal infection, antibiotic-associated diarrhea, and the consequences of HP infection eradication, studies have a high level of evidence.

This article is a reprint. Primary Publication: Gorelov AV, Zakharova IN, Khavkin AI, Kafarskaya LI, Usenko DV, Belmer SV, Kornienko EA, Privorotsky VF, Krasnov VV, Kondyurina EG, Panfilova VN, Tkhakushinova NKh, Plaksina AN, Rychkova OA, Pechkurov DV, Nizhevich AA, Fayzullina RA, Yablokova EA. Resolution of the Council of Experts “Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics”. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2022;17(1):213–221 (in Russian). DOI: 10.20953/1817-7646-2022-1-213-221. With the permission of the copyright holder. Published with reductions.

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About the authors

Aleksandr V. Gorelov

Sechenov First Moscow State Medical University (Sechenov University); Central Research Institute of Epidemiology

Author for correspondence.
Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof., Acad. RAS

Russian Federation, Moscow; Moscow

Irina N. Zakharova

Russian Medical Academy of Continuous Professional Education

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Anatolii I. Khavkin

Research Clinical Institute of Childhood

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Liudmila I. Kafarskaya

Pirogov Russian National Research Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Denis V. Usenko

Central Research Institute of Epidemiology

Email: agorelov_05@mail.ru

D. Sci. (Med.)

Russian Federation, Moscow

Sergei V. Belmer

Pirogov Russian National Research Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof., Acad. RANS

Russian Federation, Moscow

Elena A. Kornienko

Saint Petersburg State Pediatric Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Valerii F. Privorotsky

Saint Petersburg State Pediatric Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Viktor V. Krasnov

Privolzhsky Research Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Nizhny Novgorod

Elena G. Kondyurina

Novosibirsk State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Novosibirsk

Viktoriia N. Panfilova

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.)

Russian Federation, Krasnoyarsk

Nafiset Kh. Tkhakushinova

Kuban State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Assoc. Prof.

Russian Federation, Krasnodar

Anna N. Plaksina

Ural State Medical University

Email: agorelov_05@mail.ru

Cand. Sci. (Med.)

Russian Federation, Yekaterinburg

Olga A. Rychkova

Tyumen State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.)

Russian Federation, Tyumen

Dmitrii V. Pechkurov

Samara State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Samara

Aleksandr A. Nizhevich

Bashkir State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Ufa

Rezeda A. Fayzullina

Kazan State Medical University

Email: agorelov_05@mail.ru

D. Sci. (Med.), Prof.

Russian Federation, Kazan

Ekaterina A. Yablokova

Sechenov First Moscow State Medical University (Sechenov University); Research Clinical Institute of Childhood

Email: agorelov_05@mail.ru

Cand. Sci. (Med.)

Russian Federation, Moscow; Moscow

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