The role of vitamin D in the prevention and treatment of acute respiratory infections in children: A review
- Authors: Lokshina E.E.1, Zaytseva O.V.1,2
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Affiliations:
- Yevdokimov Moscow State University of Medicine and Dentistry
- Children’s State Hospital of Saint Vladimir
- Issue: No 4 (2022)
- Pages: 310-316
- Section: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/120153
- DOI: https://doi.org/10.26442/26586630.2022.4.202005
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Abstract
The highest frequency of acute respiratory infections occurs in children aged 3–7 years (preschoolers), when the child begins to meet with an increased infectious load in children's organized groups. Vitamin D deficiency or insufficiency is often detected in children with recurrent respiratory infections. At the same time, vitamin D is a complex regulator of innate and adaptive immunity, has an immunomodulatory and anti-inflammatory effect, and protects from a severe infection. The results of international and Russian studies demonstrate the feasibility of using vitamin D for the prevention and treatment of a number of respiratory infections in children and adults.
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About the authors
Evelina E. Lokshina
Yevdokimov Moscow State University of Medicine and Dentistry
Author for correspondence.
Email: elokshina@yandex.ru
ORCID iD: 0000-0001-6006-7846
Cand. Sci. (Med.), Assoc. Prof., Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation, MoscowOlga V. Zaytseva
Yevdokimov Moscow State University of Medicine and Dentistry; Children’s State Hospital of Saint Vladimir
Email: olga6505963@yandex.ru
ORCID iD: 0000-0003-3426-3426
D. Sci. (Med.), Prof., Yevdokimov Moscow State University of Medicine and Dentistry, Children’s State Hospital of Saint Vladimir
Russian Federation, Moscow; MoscowReferences
- Намазова Л.С., Ботвиньева В.В., Торшхоева Р.М., и др. Лечение и профилактика острых респираторных инфекций у часто болеющих детей, проживающих в мегаполисах. Детские инфекции. 2007;2:49-52 [Namazova LS, Botvin'eva VV, Torshkhoeva RM, et al. Lechenie i profilaktika ostrykh respiratornykh infektsii u chasto boleiushchikh detei, prozhivaiushchikh v megapolisakh. Detskie infektsii. 2007;2:49-52 (in Russian)].
- Зайцева С.В., Застрожина А.К., Бельская Е.А. Место ароматерапии в лечении и профилактике острых респираторных заболеваний. Трудный пациент. 2015;13(1-2):48-54. [Zaitseva SV, Zastrozhina AK, Bel'skaia EA. Mesto aromaterapii v lechenii i profilaktike ostrykh respiratornykh zabolevanii. Trudnyi patsient. 2015;13(1-2):48-54 (in Russian)].
- Заплатников А.Л. Современные возможности иммунопрофилактики и иммунотерапии острых респираторных инфекций у детей. Медицинский совет. 2007;1:74-6 [Zaplatnikov AL. Sovremennye vozmozhnosti immunoprofilaktiki i immunoterapii ostryh respiratornyh infekcij u detej. Medicinskij sovet. 2007;1:74-6 (in Russian)].
- Chiappini E, Santamaria F, Marseglia GL, et al. Prevention of recurrent respiratory infections. Ital J Pediatr. 2021;47(1):211. doi: 10.1186/s13052-021-01150-0
- Мельниченко Г.А., Намазова-Баранова Л.С., Громова О.А., и др. Профилактика и лечение дефицита витамина D: выбор оптимального подхода. Вопросы современной педиатрии. 2021;20(4):338-45 [Mel'nichenko GA, Namazova-Baranova LS, Gromova OA, et al. Profilaktika i lechenie defitsita vitamina D: vybor optimal'nogo podkhoda. Voprosy sovremennoi pediatrii. 2021;20(4):338-45 (in Russian)]. doi: 10.15690/vsp.v20i4.2246
- Castro LC. The vitamin D endocrine system. Arq Bras Endocrinol Metabol. 2011;55(8):566-75.
- Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
- Толстова Е.М., Сорокина Н.В. О дозировках витамина D для детей: национальные рекомендации и мировой опыт. Status praesens. Педиатрия и неонатология. 2019;3(60):73-9 [Tolstova EM, Sorokina NV. O dozirovkakh vitamina D dlia detei: natsional'nye rekomendatsii i mirovoi opyt. Status praesens. Pediatriia i neonatologiia. 2019;3(60):73-9 (in Russian)].
- Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11(11):CD008824. doi: 10.1002/14651858.CD008824
- Mazzoleni S, Magni G, Toderini D. Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study). Ital J Pediatr. 2019;45(1):18. doi: 10.1186/s13052-018-0590-x
- Wang S, Shen G, Jiang S, et al. Nutrient status of vitamin D among Chinese children. Nutrients. 2017;9(4):319.
- Al-Taiar A, Rahman A, Al-Sabah R, et al. Vitamin D status among adolescents in Kuwait: a cross-sectional study. BMJ Open. 2018;8(7):e021401. doi: 10.1136/bmjopen-2017-021401
- Суплотова Л.А., Авдеева В.А., Пигарова Е.А., и др. Дефицит витамина D в России: первые результаты регистрового неинтервенционного исследования частоты дефицита и недостаточности витамина D в различных географических регионах страны. Проблемы эндокринологии. 2021;67(2):84-92 [Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, noninterventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian)]. doi: 10.14341/probl12736
- Захарова И.Н., Мальцев С.В., Боровик Т.Э., и др. Результаты многоцентрового когортного исследования «РОДНИЧОК» по изучению недостаточности витамина D у детей раннего возраста в России. Педиатрия. Журнал им. Г.Н. Сперанского. 2015;94(1):62-7 [Zakharova IN, Mal'tsev SV, Borovik TE, et al. Rezul'taty mnogotsentrovogo kogortnogo issledovaniia “RODNIChOK” po izucheniiu nedostatochnosti vitamina D u detei rannego vozrasta v Rossii. Pediatriia. Zhurnal im. G.N. Speranskogo. 2015;94(1):62-7 (in Russian)].
- Кондратьева Е.И., Лошкова Е.В., Захарова И.Н., и др. Оценка обеспеченности витамином D детей Москвы и Московской области. Российский вестник перинатологии и педиатрии. 2021;66(2):78-84 [Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2021;66(2):78-84 (in Russian)]. doi: 10.21508/1027-4065-2021-66-2-78-84
- Braegger C, Campoy C, Colomb V, et al. Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr. 2013;56:692.
- Дорофейков В.В., Зазерская И.Е., Кузнецова Л.В., и др. Под ред. И.Е. Зазерской. Витамин D и здоровье женщины. СПб: Эко-Вектор, 2021 [Dorofeikov VV, Zazerskaia IE, Kuznetsova LV, et al. Pod red. IE Zazerskoi. Vitamin D i zdorov'e zhenshchiny. Saint Petersburg: Eko-Vektor, 2021 (in Russian)].
- Романцова Е.Б., Бабцева А.Ф., Борисенко Е.П., и др. D-дефицитное состояние у часто болеющих детей в Амурской области. Практичеcкая медицина. 2017;5(106):53-5 [Romantsova EB, Babtseva AF, Borisenko EP, et al. D-defitsitnoe sostoianie u chasto boleiushchikh detei v Amurskoi oblasti. Prakticheckaia meditsina. 2017;5(106):53-5 (in Russian)].
- Дедов И.И., Мельниченко Г.А., Пигарова Е.А., и др. Дефицит витамина D у взрослых: диагностика, лечение и профилактика: учебное пособие. М.–Тверь: Триада, 2020 [Dedov II, Mel'nichenko GA, Pigarova EA, et al. Defitsit vitamina D u vzroslykh: diagnostika, lechenie i profilaktika: uchebnoe posobie. Moscow–Tver: Triada, 2020 (in Russian)].
- Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа, 2021 [Gromova OA, Torshin IIu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2021 (in Russian)].
- Национальная программа «Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции». Союз педиатров России. М.: ПедиатрЪ, 2018 [Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii”. Soiuz pediatrov Rossii. Moscow: Pediatr, 2018 (in Russian)].
- Neme A, Seuter S. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochim Biophys Acta Gene Regul Mech. 2017;1860(9):952-61.
- Мальцев С.В., Рылова Н.В. Витамин D и иммунитет. Практическая медицина. 2015:1:114-20 [Mal'tsev SV, Rylova NV. Vitamin D i immunitet. Prakticheskaia meditsina. 2015:1:114-20 (in Russian)].
- Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med. 2010;235(9):1034-45.
- Спиричев В.Б. О биологических эффектах витамина Д. Педиатрия. 2011;90(6):113-9 [Spirichev VB. O biologicheskikh effektakh vitamina D. Pediatriia. 2011;90(6):113-9 (in Russian)].
- Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci. 2004;29(12):664-73. doi: 10.1016/j.tibs.2004.10.005
- Рылова Н.В., Мальцев С.В., Жолинский А.В. Применение витамина D в клинической практике. Практическая медицина. 2017;5(106):10-4 [Rulova NV, Maltsev SV, Zholinskiy AV. Role of vitamin D in regulation of the immune system. Prakticheskaia meditsina. 2017;5(106):10-4 (in Russian)].
- Telcian AG, Zdrenghea MT, Edwards MR, et al. Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro. Antiviral Res. 2017;137:93-101. doi: 10.1016/j.antiviral.2016.11.004
- Olliver M, Spelmink L, Hiew J, et al. Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae. J Infect Dis. 2013;208:1474-81. doi: 10.1093/infdis/jit355
- Hansdottir S, Monick MM, Lovan N, et al. Vitamin D decreases respiratory syncytial virus induction of NF-kappaBlinked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010;184:965-74. doi: 10.4049/jimmunol.0902840
- Захарова И.Н., Цуцаева А.Н., Климов Л.Я., и др. Витамин D и продукция дефензинов у детей раннего возраста. Медицинский совет. 2020;1:153-64 [Zakharova IN, Tsutsayeva AN, Klimov LYa, et al. Vitamin D and defensins production in infants. Medical Council. 2020;1:153-64 (in Russian)]. doi: 10.21518/2079-701X-2020-1-174-185
- Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3(4):300-3.
- Bergman P, Lindh AU. Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2013;8(6):e65835.
- Laaksi I, Ruohola JP, Tuohimaa P, et al. An association of serum vitamin D concentrations <40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr. 2007;86:714-7.
- Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384-90.
- Cannell JJ, Vieth R, Willett W, et al. Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic. Ann Otol Rhinol Laryngol. 2008;117:864-70.
- Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134:1129-40.
- Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr. 2011;106:1433-40.
- Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data BMJ. 2017;356:i6583. doi: 10.1136/bmj.i6583
- Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9(5):276-92. doi: 10.1016/S2213-8587(21)00051-6
- Pham H, Rahman A, Majidi A, et al. Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019;16(17):3020. doi: 10.3390/ijerph16173020
- Marchisio P, Consonni D, Baggi E, et al. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children. Pediatr Infect Dis J. 2013;32(10):1055-60. doi: 10.1097/INF.0b013e31829be0b0
- Захарова И.Н., Долбня С.В., Курьянинова, и др. Роль витамина D в формировании здоровья детей дошкольного возраста. Медицинский совет. 2021;1:37-48 [Zakharova IN, Dolbnia SV, Kur'ianinova, et al. Rol' vitamina D v formirovanii zdorov'ia detei doshkol'nogo vozrasta. Meditsinskii sovet. 2021;1:37-48 (in Russian)].
- Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-69. doi: 10.1001/jama.2020.1585
- Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054-62. doi: 10.1016/S0140-6736(20)30566-3
- Carpagnano GE, Di Lecce V, Quaranta VN, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021;44(4):765-71. doi: 10.1007/s40618-020-01370-x
- Macaya F, Paeres CE, Valls A, et al. Interaction between age and vitamin D deficiency in severe COVID-19 infection. Nutricion Hospitalaria. 2020;37(5):1039-42. doi: 10.20960/nh.03193
- Ye K, Tang F, Liao X, et al. Does serum vitamin D level affect COVID-19 infection and its severity? A case-control study. J Am Coll Nutr. 2021;40(8):724-31. doi: 10.1080/07315724.2020.1826005
- Kaufman HW, Niles JK, Kroll MH, et al. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS ONE. 2020;15(9):e0239252. doi: 10.1371/journal.pone.0239252
- Zhou Y-F, Luo B-A, Qin L-L. The association between vitamin D deficiency and community-acquired pneumonia: a meta-analysis of observational studies. Medicine. 2019;98(38):e17252.
- Каронова Т.Л., Андреева А.Т., Вашукова М.А. Уровень 25(ОН)D в сыворотке крови у больных COVID-19. Журнал инфектологии. 2020;12(3):21-7 [Karonova TL, Andreeva AT, Vashukova MA. Uroven' 25(ON)D v syvorotke krovi u bol'nykh COVID-19. Zhurnal infektologii. 2020;12(3):21-7 (in Russian)]. doi: 10.22625/2072-6732-2020-12-3-21-27
- Povaliaeva A, Rozhinskaya LYa, Pigarova EA, et al. Vitamin D Metabolism Is Significantly Impaired in COVID-19 Inpatients. Journal of the Endocrine Society. 2021;5(Suppl. 1):A281-2. doi: 10.1210/jendso/bvab048.572
- Oscanoa TJ, Amado J, Vidal X, et al. The relationship between the severity and mortality of SARS-CoV-2 infection and 25-hydroxyvitamin D concentration – a metaanalysis. Adv Respir Med. 2021;89:145-57.
- Shoemaker ME, Huynh LM, Smith CM, et al. Immunomodulatory Effects of Vitamin D and Prevention of Respiratory Tract Infections and COVID-19. Top Clin Nutr. 2022;37(3):203-17. doi: 10.1097/TIN.0000000000000284
- Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;62(4):60-84 [Pigarova EA, Rozhinskaia LIa, Belaia ZhE, et al. Klinicheskie rekomendatsii Rossiiskoi assotsiatsii endokrinologov po diagnostike, lecheniiu i profilaktike defitsita vitamina D u vzroslykh. Problemy endokrinologii. 2016;62(4):60-84 (in Russian)]. doi: 10.14341/probl201662460-84
- Остеопороз: клинические рекомендации. 2021. Режим доступа: https://cr.minzdrav.gov.ru/recomend/87_4. Ссылка активна на 15.07.2022 [Osteoporoz: klinicheskie rekomendatsii. 2021. Available at: https://cr.minzdrav.gov.ru/recomend/87_4. Accessed: 15.07.2022 (in Russian)].
- Духанин А.С. Препараты витамина D: от действующего начала к терапевтическим эффектам. Лечащий врач. 2022;9:66-71 [Dukhanin AS. Vitamin D drug formulation: from active substance to therapeutic effects. Lechashchii vrach. 2022;9:66-71 (in Russian)]. doi: 10.51793/OS.2022.25.9.001
- Holmberg I, Aksnes L, Berlin T, et al. Absorption of a pharmacological dose of vitamin D3 from two different lipid vehicles in man: comparison of peanut oil and a medium chain triglyceride. Biopharm Drug Dispos. 1990;11(9):807-15. doi: 10.1002/bdd.2510110908
- Meza-Meza MR, Ruiz-Ballesteros AI, de la Cruz-Mosso U. Functional effects of vitamin D: From nutrient to immunomodulator. Crit Rev Food Sci Nutr. 2020;62(11):3042-62. doi: 10.1080/10408398.2020.1862753
- Marwaha RK, Dabas A. Bioavailability of nanoemulsion formulations vs conventional fat soluble preparations of cholecalciferol (D3) – An overview. J Clin Orthop Trauma. 2019;10(6):1094-6. doi: 10.1016/j.jcot.2019.07.014
