Characteristics of congenital and hereditary factors and their role in the genesis of vegeto-vascular dysfunction by hypotensive type

Materials and methods. We examined 89 adolescents aged 11 to 14 years suffering from vegetative-vascular dysfunction (VVD) by the antihypertensive type, among them 36 adolescents in whom VVD was combined with grade I thyroid hyperplasia, and 53 teenagers with VVD a history of indications of perinatal damage to the central nervous system (PDCNS). The control group consisted of 69 healthy adolescents of a similar age. All subjects were typed with 15 antigens of group A and 24 antigens of group B of the main histocompatibility complex HLA. Results. When determining the association strength of typed antigens with VVD with the enlargement of the thyroid gland of the first degree (VVDTG), the most pronounced relationship was found for B44 antigen, to a lesser extent B15 and B5 antigens, as well as antigen A1. Association with PDCNS was most pronounced for antigens B44 and A29. The association with B13 antigen disease was strong enough. To a slightly lesser extent, it was determined for antigens A25 and A19. Significantly more frequent occurrence in adolescents with VVD of B44 antigen, both with concomitant hyperplasia of the thyroid gland, and in the presence of anamnestic indications of damage to the central nervous system transferred in the perinatal period, indicate a similar mechanism of inheritance and development of VVD in adolescents. The presence of the B44 antigen in a child makes it possible to predict with a high degree of probability the possibility of developing VVD.

adolescents, vegetative-vascular dysfunction, hyperplasia of the thyroid gland, antigen