Derangement of the infant microbiome development: what a pediatrician needs to know. A review
- Authors: Zakharova I.N.1, Berezhnaya I.V.1, Dmitrieva D.K.1
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Issue: No 3 (2023)
- Pages: 108-113
- Section: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/602444
- DOI: https://doi.org/10.26442/26586630.2023.3.202392
- ID: 602444
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Abstract
The research on the microbiome and microbiota of different human ecological niches and their impact on human health showed a significant breakthrough in the last decade. It is known that minor microbial contamination is present even in the fetus in utero, inducing immunological resistance. Immediately after birth, the baby rapidly becomes colonized by maternal and environmental microorganisms. The mode of delivery impacts the number of microbes and species composition and subsequent changes in the infant's immune response. A high risk of early onset of atopic march has been reported in children born by cesarean section and treated with antibacterial drugs in early life. This paper reviews the results of recent studies of the effect of the probiotic based on the two most studied strains of Lactobacillus rhamnosus GG and Bifidobacterium lactis BS01 (Probielle Baby) on intestinal microbiota development and the prospects of its use for correcting disorders in children at high risk of atopy.
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About the authors
Irina N. Zakharova
Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0003-4200-4598
D. Sci. (Med.), Prof., Russian Medical Academy of Continuous Professional Education
Russian Federation, MoscowIrina V. Berezhnaya
Russian Medical Academy of Continuous Professional Education
Email: berezhnaya-irina26@yandex.ru
ORCID iD: 0000-0002-2847-6268
Cand. Sci. (Med.), Russian Medical Academy of Continuous Professional Education
Russian Federation, MoscowDiana K. Dmitrieva
Russian Medical Academy of Continuous Professional Education
Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0002-1593-0732
Graduate Student, Russian Medical Academy of Continuous Professional Education
Russian Federation, MoscowReferences
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