On the issue of symptomatic treatment of respiratory infections in children during the COVID-19 season

Cover Page

Cite item

Full Text

Abstract

The current epidemic season is characterized by a high incidence of acute respiratory viral infections and a new coronavirus infection among children. A significant part of children suffer from respiratory infections in mild and moderately severe forms, and only need symptomatic therapy, which includes antipyretic therapy. Both with a banal respiratory infection, and with COVID-19, ibuprofen and paracetamol can be used.

Full Text

Restricted Access

About the authors

Irina N. Zakharova

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: zakharova-rmapo@yandex.ru

Doctor of Medical Sciences, Professor, Head of the Department. acad. G.N. Speransky, Honored Doctor of the Russian Federation

Russian Federation, Moscow

References

  1. Усенко Д.В., Горелова Е.А., Каннер Е.В. Рациональный подход к терапии ОРВИ и гриппа в клинической практике врача-педиатра. РМЖ. 2015; 3: 174. [Usenko D.V., Gorelova E.A., Kanner E.V. Ratsional’nyi podkhod k terapii ORVI i grippa v klinicheskoi praktike vracha-pediatra. RMZh. 2015; 3: 174 (in Russian).]
  2. CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children – United States, February 12 – April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69 (14): 422–6.
  3. Wang W, Xu Y, Gao R et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens JAMA 2020; 323 (18): 1843–4.
  4. Методические рекомендации «Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID-19) у детей». Версия 2 (утв. Минздравом России). [Metodicheskie rekomendatsii “Osobennosti klinicheskikh proiavlenii i lecheniia zabolevaniia, vyzvannogo novoi koronavirusnoi infektsiei (COVID-19) u detei”. Versiia 2 (utv. Minzdravom Rossii) (in Russian).]
  5. Available from: https://www.nice.org.uk/guidance/ng143/chapter/Recommendations#antipyretic-interventions
  6. Sullivan JE, Farrar HC. Section on Clinical Pharmacology and Therapeutics; Committee on Drugs. Fever and antipyretic use in children. Pediatrics 2011; 127 (3): 580–7.
  7. Hay AD, Costelloe C, Redmond NM et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ 2008; 337: a1302.
  8. Kelley MT, Walson PD, Edge JH et al. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. Clin Pharmacol Therapeutics 1992; 52 (2): 181–9.
  9. Kanabar D. A practical approach to the treatment of low-risk childhood fever. Drugs R D 2014; 14 (2): 45–55. doi: 10.1007/s40268-014-0052-x
  10. Hämäläinen ML. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. Neurology 1997; 48: 103–7.
  11. Poddighe D, Brambilla I, Licari A, Marseglia G. Ibuprofen for Pain Control in Children: New Value for an Old Molecule. Pediatr Emerg Care 2019; 35 (6): 448–53.
  12. Pierce CA, Voss B. Efficacy and Safety of Ibuprofen and Acetaminophen in Children and Adults: A Meta-Analysis and Qualitative Review. Ann Pharmacother 2010; 44 (3): 489–506.
  13. Southey ER, Soares-Wieser K, Kleijnen J. Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. Curr Med Res Opin 2009; 25 (9): 2207–22.
  14. Баранов А.А., Таточенко В.К., Бакрадзе М.Д. Лихорадящий ребенок. Протоколы диагностики и лечения. М., 2015. [Baranov A.A., Tatochenko V.K., Bakradze M.D. Likhoradiashchii rebenok. Protokoly diagnostiki i lecheniia. Moscow, 2015 (in Russ.).]
  15. Kanabar D et al. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 2007; 29: 2716–23.
  16. Kanabar D. A clinical and safety review of paracetamol and ibuprofen in children. Inflammopharmacology 2017; 25 (1): 1–9. doi: 10.1007/s10787-016-0302-3
  17. Lesko SM, Mitchell AA. An Assessment of the Safety of Pediatric Ibuprofen: A Practitioner-Based Randomized Clinical Trial. JAMA. 1995; 273 (12): 929–33.
  18. Barbagallo M, Sacerdote P. Ibuprofen in the treatment of children’s inflammatory pain: a clinical and pharmacological overview. Minerva Pediatr 2019; 71 (1): 82–99. doi: 10.23736/S0026-4946.18.05453-1
  19. Нурофен® для детей, суспензия для приема внутрь (апельсиновая, клубничная). Фармакотерапевтическая группа: НПВП. Рег. уд. П №014745/01. [Nurofen® dlia detei, suspenziia dlia priema vnutr’ (apel’sinovaia, klubnichnaia). Farmakoterapevticheskaia gruppa: NPVP. Reg. ud. P no. 014745/01 (in Russian).]
  20. Ушкалова Е. Проблемы безопасности анальгетиков у детей. Врач. 2012; 8: 32–6. [Ushkalova E. Problemy bezopasnosti anal’getikov u detei. Vrach. 2012; 8: 32–6 (in Russian).]
  21. Rainsford KD. Pharmacology and toxicology of ibuprofen. In: Rainsford KD. Ibuprofen. A critical bibliographic review. London: Taylor & Francis, 1999; p. 145–27.
  22. Argentieri J, Morrone K, Pollack Y. Acetaminophen and Ibuprofen overdosage. Pediatr Rev 2012; 33: 188–9.

Supplementary files

Supplementary Files
Action
1. Fig. 1. The mechanism of action of antipyretics ibuprofen and paracetamol.

Download (71KB)
Indexing metadata
2. Fig. 2. Comparative efficacy of paracetamol and ibuprofen in pain syndrome [10].

Download (34KB)
Indexing metadata
3. Fig. 3. Comparative efficacy of ibuprofen and paracetamol in reducing symptoms of malaise and discomfort in children [7].

Download (42KB)
Indexing metadata

Copyright (c) 2020 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74329 от 19.11.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies