The role of short-chain fatty acids in the formation of non-alcoholic fatty liver disease in children: A review

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Abstract

This review examines scientific publications that describe the main properties of microbiota metabolites and their participation in the pathogenetic connection of the intestinal-liver system in children with non-alcoholic fatty liver disease (NAFLD). Normal metabolism of short-chain fatty acids (SCFA) is one of the main conditions for maintaining microbiocinosis, eliminating the main pathological trigger factors. Changes in the qualitative and quantitative characteristics of SCFA can play a significant role in the development of complications in NAFLD. Studying the role of SCFAs in NAFLD in childhood will answer questions about their participation in the main links in the pathogenesis of metabolic and cardiovascular diseases, such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. The data obtained are necessary for the development of personalized correction of the species composition of microorganisms and their metabolites at the initial stages of the disease before the development of significant fibrogenesis.

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Olesya V. Pervishko

Kuban State Medical University

Author for correspondence.
Email: ole-pervishko@yandex.ru
ORCID iD: 0000-0003-1083-2807

Cand. Sci. (Med.), Assoc. Prof.

Russian Federation, Krasnodar

Maria D. Ardatskaya

Central State Medical Academy of the President of the Russian Federation

Email: ole-pervishko@yandex.ru
ORCID iD: 0000-0001-8150-307X

Sci. (Med.), Prof.

Russian Federation, Moscow

Irina N. Zakharova

Russian Medical Academy of Continuous Professional Education

Email: ole-pervishko@yandex.ru
ORCID iD: 0000-0003-4200-4598

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Natalia G. Soboleva

Clinic “G8 Center”

Email: ole-pervishko@yandex.ru
ORCID iD: 0009-0004-9727-2543

Sci. (Med.), Prof.

Russian Federation, Krasnodar

Ulyana A. Stinskaya

Kuban State Medical University

Email: ole-pervishko@yandex.ru
ORCID iD: 0009-0008-4638-4608

Student

Russian Federation, Krasnodar

Irina V. Berezhnaya

Russian Medical Academy of Continuous Professional Education

Email: ole-pervishko@yandex.ru
ORCID iD: 0000-0002-2847-6268

Cand. Sci. (Med.)

Russian Federation, Moscow

Svetlana N. Borzakova

Russian Medical Academy of Continuous Professional Education

Email: ole-pervishko@yandex.ru

Cand. Sci. (Med.)

Russian Federation, Moscow

Diana K. Dmitrieva

Russian Medical Academy of Continuous Professional Education

Email: ole-pervishko@yandex.ru
ORCID iD: 0000-0002-1593-0732

Graduate Student

Russian Federation, Moscow

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2. Fig. 1. Main effects of short-chain fatty acids in normal and liver disease.

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3. Fig. 2. Schematic representation of activation of TOLL- and NOD-like receptors of liver cells under the action of intestine trigger factors.

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