Features of hypoxic resistance in children with bronchial asthma who have undergone a new coronavirus infection

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Abstract

Aim. To study the characteristics of resistance/sensitivity to normobaric hypoxia in 50 children with bronchial asthma (BA) from 9 to 12 years old, 24 of them after a previous coronavirus infection СOVID-19.

Materials and methods. A normobaric hypoxic test (HT) was carried out by creating hypoxemia (threshold level SpO2 80%) during mask inhalation of a gas mixture with 10–11% O2 by a child using a ReOxy Cardio apparatus (Ai Mediq S.A., Luxembourg). The data obtained were compared with the results in a group of healthy children the same age.

Results. It was found that the integral level of hypoxic resistance of children with BA was generally lower in comparison with the group of healthy children, which was manifested in lower values of the hypoxic index (3.1±1.4, in the group of healthy children – 4.9±2.8, p=0.005), a significantly increased level of tachycardia and a hypotonic response to dosed hypoxia.

Conclusion. When typing reactions to HT, it was found that in children with BA, the type of low resistance to hypoxia is more common (to a greater extent in children with BA after a coronavirus infection), which confirms the need to involve such children in comprehensive rehabilitation programs.

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About the authors

Oleg S. Glazachev

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: glazachev@mail.ru
ORCID iD: 0000-0001-9960-6608

D. Sci. (Med.), Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Natalia A. Geppe

Sechenov First Moscow State Medical University (Sechenov University)

Email: geppe@mail.ru
ORCID iD: 0000-0003-0547-3686

D. Sci. (Med.), Prof., Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Iurii S. Timofeev

Sechenov First Moscow State Medical University (Sechenov University)

Email: ust.0747@gmail.com
ORCID iD: 0000-0002-3665-5127

Graduate Student, Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Marina D. Shakhnazarova

Sechenov First Moscow State Medical University (Sechenov University)

Email: marinashakh@mail.ru
ORCID iD: 0000-0003-3512-5455

Cand. Sci. (Med.), Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Natalia G. Kolosova

Sechenov First Moscow State Medical University (Sechenov University)

Email: kolosovan@mail.ru
ORCID iD: 0000-0001-5071-9302

Cand. Sci. (Med.), Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Vlada G. Samartseva

Sechenov First Moscow State Medical University (Sechenov University)

Email: glazachev@mail.ru
ORCID iD: 0000-0003-1266-312X

Graduate Student, Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Elena N. Dudnik

Sechenov First Moscow State Medical University (Sechenov University)

Email: elenad.72@list.ru
ORCID iD: 0000-0003-4571-1781

Cand. Sci. (Biol.), Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Aleksandr B. Malakhov

Sechenov First Moscow State Medical University (Sechenov University)

Email: alexis4591m@mail.ru
ORCID iD: 0000-0002-2686-8284

D. Sci. (Med.), Prof., Sechenov First Moscow State Medical University

Russian Federation, Moscow

Elena V. Frolkova

Sechenov First Moscow State Medical University (Sechenov University)

Email: glazachev@mail.ru

Cand. Sci. (Med.), Sechenov First Moscow State Medical University

Russian Federation, Moscow

Irina I. Kalinovskaya

Children’s Bronchopulmonary Sanatorium №15

Email: super_irina@bk.ru
ORCID iD: 0000-0002-3327-4687

Cand. Sci. (Med.), Children’s Bronchopulmonary Sanatorium №15

Russian Federation, Moscow

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