Email this article Visceral leishmaniasis in children (own results and literature analysis)
- Authors: Volkova G.I.1,2, Smirnova M.I.1, Delyagin W.M.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology
- Russian Children's Clinical Hospital, Pirogov Russian National Research Medical University
- Issue: No 3 (2020)
- Pages: 80-83
- Section: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/57116
- DOI: https://doi.org/10.26442/26586630.2020.3.200344
- ID: 57116
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Abstract
Leishmaniasis is a tropical parasitic infection with a preferred lesion in children. Leishmaniasis, perceived as an infection in hot and humid regions, is not always taken into account in the differential diagnostic search in febrile children with splenomegaly, the degree of which prevails over hepatic anemia. The geographical factor is not taken into account. In our observations, the period from the first symptoms to the diagnosis ranged from 0.5 to 17 months. The diagnosis is confirmed by the results of bone marrow puncture, immunological tests. Treatment is based on the use of antimony drugs. Often, adverse reactions are recorded in the form of an increase in hepatic enzymes, bilirubinemia, anemia. Prevention is the avoiding of mosquito bites.
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About the authors
Galina I. Volkova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology; Russian Children's Clinical Hospital, Pirogov Russian National Research Medical UniversityMoscow, Russia
Mariia I. Smirnova
Dmitry Rogachev National Medical Research Center of Pediatric HematologyMoscow, Russia
Wassili M. Delyagin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology
Email: delyagin-doktor@yandex.ru
Moscow, Russia
References
- Aronson N, Copeland N, Magill A. Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis. In: Benner J, Dolin R, Blaser M (Eds.) Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 9th Ed. 2020; 3321-40.e4.
- Заславский Д.В., Андриенко Е.М., Александрова И.Ю. и др. Верификация лейшманиоза кожи. Вестник дерматологии и венерологии. 2014; 5: 91-5.
- Hotez P, Lo N. Neglected tropical diseases: public health control programs and mass drug administration. In: Ryan E, Hill D, Solomin T et al. (Eds.) Hunter’s Tropical Medicine and Emerging Infectious Diseases. 2020. 10th Ed.; 209-13.
- Garcia L. Leishmaniasis. In: Cherry J, Harrison G, Kaplan Sh et al. (Eds.) Feigin and cherry’s textbook of pediatric infectious diseases. 8th Ed. 2019; 2178-86.e2.
- Leishmaniasis. 2014. http://www.who.int/topics/leishmaniasis/en/
- Murray H, Berman J, Davies C et al. Advances in leishmaniasis. Lancet 2005; 366 (9496): 1561-77.
- Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Centers for Diseases Control and Prevention. https://www.cdc.gov/parasites/leishmaniasis/epi.html
- Gradoni L. Leishmaniasis. In: Kellerman R, Rakel D (Eds.). Conn’s Current Therapy. 2020; 577-80.
- De Menezes J, Koushik A, Das S et al. Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins. Cell Microbiol 2017; 19 (3). doi: 10.1111/cmi.12668
- Ready P. Biology of phlebotomine sand flies as vectors of disease agents. An Rev Entomol 2013; 58: 227-50.
- Pace D. Leishmaniasis. J Infect. 2014; 69; Suppl. 1: 10-8. doi: 10.1016/j.jinf.2014.07.016
- Hewitt S, Reyburn H, Ashford R, Rowland M. Anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: vertical distribution of cases in apartament blocks. Transact Royal Society Tropical Med Hyg 1998; 92 (3): 273-4.
- World Health Organization (WHO). First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases. Geneva, 2010.
- Kevric I, Cappel M, Keeling J. New World and Old World Leishmania Infections. A Practical Review. Dermatol Clin 2015; 33 (3): 579-93.
- Banuls A, Hide M, Pruqnolle F Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans. Adv Parasitol 2007; 64: 1-109.
- Chappuis F, Sundar S, Hailu A et al. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 2007; 5 (11): 873-82.
- Sakthianandeswaren A, Foote S, Handman E. The role of host genetics in leishmaniasis. Trends Parasitol 2009; 25 (8): 383-91.
- Zhang W, Matlashewski G. Characterization of the A2-A2rel gene cluster in Leish-mania donovani: involvement of A2 in visceralization during infection. Mol Microbiol 2001; 39 (4): 935-48.
- Okwor I, Uzonna J. Social and Economic Burden of Human Leishmaniasis. Am J Trop Med Hyg 2016; 94 (3): 489-93.
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