Component changes of body composition in children with obesity and the development of the left ventricle hypertrophy

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Abstract

We analyzed the changes in LVMI depending on the BMI and the body composition of the body in children 10–17 years of age.

Materials and methods. 112 children were examined: 60 obese children, 26 with overweight and 26 patients in the control group. All the children underwent anthropometry with the calculation of BMI, evaluation of the body composition of the body according to bioimpedance analysis, echocardiography with calculation of LVM and LVMI and detection of arterial hypertension according to the data of daily monitoring of arterial pressure.

Results. Children with obesity had large sizes of LV, LVM and LVMI. Arterial hypertension was noted in 60.2% of cases among patients with excess body weight, but significant differences in LVMI in children with and without arterial hypertension were not received. In children with increasing body weight there is an increase in all body components, especially fat mass. With an increase in body weight, the increase in LVM occurs to a greater extent than the increase in active cell mass (reflects the development of LV hypertrophy in obesity). When analyzing the proportions between the LVM and the body components, it is seen that with the development of obesity, LVM in relation to the active cell mass, extracellular and intracellular water sectors increases, but in relation to fat mass significantly decreases.

Conclusion. The outstripping growth of LVM in relation to the active cell mass and intra- and extracellular water sectors and the «deficit» of LVM in relation to the fat mass were revealed. In children with obesity, there is no evidence of water retention and the development of left ventricular hypertrophy is not associated with an increase in volume loading, but is apparently due to non-hemodynamic factors.

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About the authors

Anastasia G. Kedrinskaya

Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University

Author for correspondence.
Email: leonova_ia@mail.ru

Researcher Officer, Assistant of Professor

Russian Federation, Saint Petersburg

Galina I. Obraztsova

Almazov National Medical Research Centre

Email: leonova_ia@mail.ru

D. Sci. (Med.)

Russian Federation, Saint Petersburg

Natalia B. Kuprienko

Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University

Email: leonova_ia@mail.ru

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Irina A. Leonova

Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University

Email: leonova_ia@mail.ru

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

References

  1. Obesity and overweight. Media centre WHO: Fact sheet; Updated June 2016. http://www.who.int/mediacentre/factsheets/fs311/en/
  2. Klein S, Burke L, Bray G et al. American Heart Association Council on Nutrition, Physical Activity, and Metabolism; American College of Cardiology Foundation. Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation 2004; 110: 2952–67.
  3. Black R, Victora C, Walker S et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 2013; 382: 427–51.
  4. Sabo R, Yen M, Daniels S et al. Associations between childhood body size, composition, blood pressure and adult cardiac structure: the fels longitudinal study. PLoS One 2014; 9 (9): e106333. doi: 10.1371/journal.pone.0106333
  5. Li X, Li S, Ulusoy E et al. Childhood adiposity as a predictor of cardiac mass in adulthood. The Bogalusa Heart Study. Circulation 2004; 110 (22): 3488–92.
  6. Friedemann C, Heneghan C, Mahtani K et al. Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis. BMJ 2012; 345. doi: 10.1136/bmj.e4759
  7. Murdolo G, Angeli F, Reboldi G et al. Left Ventricular Hypertrophy and Obesity: Only a Matter of Fat? High Blood Press Cardiovasc Prev 2015; 22 (1): 29–41.
  8. de Simone G, Izzo R, De Luca N et al. Left ventricular geometry in obesity: is it what we expect? Nutr Metab Cardiovasc Dis 2013; 23: 905–12.
  9. Oh G, Wong C, Begin B et al. Whole-body single-frequency bioimpedance analysis in pediatric hemodialysis patients. Pediatr Nephrol 2014; 29 (8): 1417–23.
  10. De Simone G, Devereux R, Kizer J et al. Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN Study1–3. Am J Clin Nutr 2005; 81: 757–61.
  11. Kim N, Hong Y, Jung J et al. The relationships of body mass index, waist-to-height ratio, and body fat percentage with blood pressure and its hemodynamic determinants in Korean adolescents: a school-based study. Korean J Pediatr 2013; 56 (12): 526–33.
  12. Dai S, Harrist R, Rosenthal G et al. Effects of Body Size and Body Fatness on Left Ventricular Mass in Children and Adolescents: Project HeartBeat! Am J Prev Med 2009; 37 (Suppl. 1): 97–104.
  13. WHO. Child Growth Standards. Geneva. http://who.int/childgrowth/standards
  14. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114 (Suppl. 2): 555–76.
  15. Zoccali C, Benedetto F, Mallamaci F et al. Prognostic impact of the indexation of left ventricular mass in patients undergoing dialysis. J Am Soc Nephrol 2001; 12: 2768–74.
  16. Soergel M, Kirschstein M, Busch C et al. Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects. J Pediatr 1997; 130 (2): 178–84.
  17. Александров А.А., Кисляк О.А., Леонтьева И.В., Розанов В.Б. Диагностика, лечение и профилактика артериальной гипертензии у детей и подростков. Российские рекомендации (второй пересмотр). Кардиоваскулярная терапия и профилактика. 2009; 8 (4 Прил. 1): 1–32. [Aleksandrov A.A., Kisliak O.A., Leont’eva I.V., Rozanov V.B. Diagnostics, treatment and prevention of arterial hypertension in children and adolescents. Russian recommendations (second revision). Cardiovascular Therapy and Prevention. 2009; 8 (4 Suppl. 1): 1–32 (in Russian).]
  18. Шляхто Е.В., Конради А.О. Ремоделирование сердца при гипертонической болезни. Сердце. 2002; 1 (5): 232–4. [Shliakhto E.V., Konradi A.O. Heart remodeling in hypertension. The Heart. 2002; 1 (5): 232–4 (in Russian).]
  19. Фомина И.Г., Дьякова Т.А. Гипертрофия левого желудочка при артериальной гипертензии и риск развития аритмий. Кардиоваскулярная терапия и профилактика. 2006; 5 (8): 83–9. [Fomina I.G., Dyakova T.A. Left ventricular hypertrophy in arterial hypertension and arrhythmia risk. Cardiovascular Therapy and Prevention. 2006; 5 (8): 83–9 (in Russian).]
  20. Барсуков А.В., Шустов С.Б. Артериальная гипертензия. Клиническое профилирование и выбор терапии. СПб.: ЭЛБИ-СПб, 2004. [Barsukov A.V., Shustov S.B. Arterial hypertension. Clinical profiling and therapy selection. Saint Petersburg: ELBI-SPb, 2004 (in Russian).]
  21. Alpert M. Obesity cardiomyopathy; pathophysiology and evolution of the clinical syndrome. Amer J Med Sci 2001; 321: 225–36.
  22. De Divitus O, Fazio S, Petitto M et al. Obesity and cardiac function. Circulation 1981; 64 (3): 477–81.
  23. Дедов И.И., Александров А.А., Кухаренко С.С. Ожирение: кардиальные проблемы. РМЖ. 2006; 13: 930. [Dedov I.I., Aleksandrov A.A., Kukharenko S.S. Ozhirenie: kardial’nye problemy. RMJ. 2006; 13: 930 (in Russian).]
  24. Ховаев Ю.А., Берг М.Д., Ховаева Я.Б. Ремоделирование сердца у лиц с предгипертонией. Материалы Всероссийского клинико-диагностического форума. Тюмень, 2005. [Khovaev Iu.A., Berg M.D., Hovaeva Ia.B. Heart remodeling in persons with prehypertension. Materials of the All-Russian Clinical and Diagnostic Forum. Tiumen, 2005 (in Russian).]
  25. Verdecchia P, Reboldi G, Schillaci G et al. Value of a simple echocardiographic linear predictor of left ventricular mass in systemic hypertension. Am J Cardiol 1999; 84 (10): 1209–14.
  26. Чумакова Г.А., Веселовская Н.Г., Козаренко А.А., Воробьева Ю.В. Особенности морфологии, структуры и функции сердца при ожирении. Рос. кардиол. журн. 2012; 4: 93–9. doi: 10.15829/1560-4071-2012-4-93-99 [Chumakova G.A., Veselovskaya N.G., Kozarenko A.A., Vorobyeva Yu.V. Heart morphology, structure, and function in obesity. Rus J Cardiol. 2012; 4: 93–9. doi: 10.15829/1560-4071-2012-4-93-99 (in Russian).]
  27. Бояринова М.А., Ротарь О.П., Конради А.О. Адипокины и кардиометаболический синдром. Артериальная гипертензия. 2014; 20 (5): 423–32. doi: 10.18705/1607-419X-2014-20-5-422-432 [Boyarinova M.A., Rotar O.P., Konradi A.O. Adipokines and cardiometabolic syndrome. Arterial Hypertension. 2014; 20 (5): 422–32. doi: 10.18705/1607-419X-2014-20-5-422-432 (in Russian).]
  28. Кедринская А.Г., Образцова Г.И., Леонова И.А. Компонентный состав тела у детей с избыточной массой тела и ожирением. Рос. педиатр. журн. 2018; 21 (2): 73–7. [Kedrinskaya A.G., Obraztsova G.I., Leonova I.A. Component composition of the body in children with excessive body mass and obesity. Rus Pediatr J. 2018; 21 (2): 73–7 (in Russian).]
  29. Zhu W, Li M, Huang X et al. Association of hyperviscosity and subclinical atherosclerosis in obese schoolchildren. Eur J Pediatr 2005; 164 (10): 639–45.
  30. Peters SA, Woodward M, Rumley A et al. Plasma and blood viscosity in the prediction of cardiovascular disease and mortality in the Scottish Heart Health Extended Cohort Study. Eur J Prev Cardiol 2017; 24 (2): 161–7.

Supplementary files

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2. Fig. 1. Correlation of left ventricular myocardial mass (LVMM) with bioimpedance measurements.

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3. Fig. 2. Changes in body composition (kg/m2,7) and LVMM index (g/m2,7) in children with different body weights.

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4. Fig. 3. Proportions of LVMM in relation to body components in children with different body weight (g/kg).

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