Component changes of body composition in children with obesity and the development of the left ventricle hypertrophy

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Abstract

We analyzed the changes in LVMI depending on the BMI and the body composition of the body in children 10–17 years of age.

Materials and methods. 112 children were examined: 60 obese children, 26 with overweight and 26 patients in the control group. All the children underwent anthropometry with the calculation of BMI, evaluation of the body composition of the body according to bioimpedance analysis, echocardiography with calculation of LVM and LVMI and detection of arterial hypertension according to the data of daily monitoring of arterial pressure.

Results. Children with obesity had large sizes of LV, LVM and LVMI. Arterial hypertension was noted in 60.2% of cases among patients with excess body weight, but significant differences in LVMI in children with and without arterial hypertension were not received. In children with increasing body weight there is an increase in all body components, especially fat mass. With an increase in body weight, the increase in LVM occurs to a greater extent than the increase in active cell mass (reflects the development of LV hypertrophy in obesity). When analyzing the proportions between the LVM and the body components, it is seen that with the development of obesity, LVM in relation to the active cell mass, extracellular and intracellular water sectors increases, but in relation to fat mass significantly decreases.

Conclusion. The outstripping growth of LVM in relation to the active cell mass and intra- and extracellular water sectors and the «deficit» of LVM in relation to the fat mass were revealed. In children with obesity, there is no evidence of water retention and the development of left ventricular hypertrophy is not associated with an increase in volume loading, but is apparently due to non-hemodynamic factors.

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About the authors

Anastasia G. Kedrinskaya

Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University

Author for correspondence.
Email: leonova_ia@mail.ru

Researcher Officer, Assistant of Professor

Russian Federation, Saint Petersburg

Galina I. Obraztsova

Almazov National Medical Research Centre

Email: leonova_ia@mail.ru

D. Sci. (Med.)

Russian Federation, Saint Petersburg

Natalia B. Kuprienko

Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University

Email: leonova_ia@mail.ru

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Irina A. Leonova

Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University

Email: leonova_ia@mail.ru

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Correlation of left ventricular myocardial mass (LVMM) with bioimpedance measurements.

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3. Fig. 2. Changes in body composition (kg/m2,7) and LVMM index (g/m2,7) in children with different body weights.

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4. Fig. 3. Proportions of LVMM in relation to body components in children with different body weight (g/kg).

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