Study of the effect of using a foam form with ceramides and a cholesterol-phytosterol complex in patients with atopic dermatitis

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Abstract

Background. In developed countries more than 20% of children have atopic dermatitis (AD). Clinical guidelines unite in the recommendation to use moisturizers/emollients as therapy mainstay. Deeper understanding of AD pathogenesis stimulates development of new, therapeutic moisturizers. To such moisturizers belong ceramide-containing moisturizers, in particular foam for moisturizing and nourishing dry sensitive skin with ceramides and a cholesterol-phytosterol complex.

Aim. To study effects of foam for moisturizing and nourishing dry sensitive skin with ceramides and a cholesterol-phytosterol complex on the course mild to moderate severity AD.

Materials and methods. In this prospective cohort study 30 children 3 to 17 years of age with mild to moderate severity AD were enrolled. They applied moisturizing foam skin lesion, surrounding skin and dry skin areas for 4 weeks. For all participants severity of AD was scored with SOCARD, EASI, IGA, skin pH, moisture and transepidermal water loss (TEWL) were measured and severity of itching and xerosis was elicited with visual analogue scale.

Results. Severity of AD in children who applied foam decreased on 22.8 score points with SCORAD, and on 3.1 points with EASI (for both indices p<0.001). Skin moisture during treatment period increased (23.5% to baseline; p<0.001), and TEWL decreased (for 5.45 g/h×m2; p<0.001); skin pH decreased 0.2 unit to normal values (р=0.002). It was found that skin moisture and TEWL correlate with AD severity so that less severe AD associated with moisture increase and TEWL decrease. As “good” and “excellent” rated foam smell 100% (95% CI 88.4–100%) respondents, consistence – 90% (95% CI 73.5–98.0%), and ease of use – 97% (95% CI 82.8–99.9%) respondents.

Conclusion. Moisturizing foam with ceramides and a cholesterol-phytosterol complex might be used in AD therapy.

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About the authors

Denis V. Zaslavsky

Saint-Petersburg State Pediatric Medical University

Author for correspondence.
Email: venerology@gmail.com
ORCID iD: 0000-0001-5936-6232
SPIN-code: 5832-9510

D. Sci. (Med.), Prof.

Russian Federation, Saint Peterburg

Anna N. Barinova

Mechnikov North-Western State Medical University; City Hospital No. 26

Email: anna_n_barinova@mail.ru
ORCID iD: 0000-0002-8180-9340
SPIN-code: 2010-4354

D. Sci. (Med.)

Russian Federation, Saint Petersburg; Saint Petersburg

Sviatoslav L. Plavinskij

Mechnikov North-Western State Medical University

Email: s.plavinskij@szgmu.ru
ORCID iD: 0000-0001-9159-6177
SPIN-code: 5660-4661

D. Sci. (Med.)

Russian Federation, Saint Petersburg

Maria I. Zelianina

The Pierre Wolkenstein French Dermatological Clinic, LLC

Email: m.zelianina@rambler.ru
ORCID iD: 0000-0002-0172-9763

Dermatologist

Russian Federation, Saint Petersburg

Elena S. Manylova

Saint-Petersburg State Pediatric Medical University

Email: tulechka78@mail.ru

Dermatologist

Russian Federation, Saint Peterburg

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Supplementary files

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2. Fig. 1. Improvement of SCORAD and EASI indices at the visits 2 and 3.

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3. Fig. 2. Improvement of skin hydration at the visits 2 and 3 versus baseline.

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4. Fig. 3. Improvement (reduction) of transepidermal water loss (TEWL) and pH depending on the baseline. Since there was no improvement of 50%, no data are reported.

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5. Fig. 4. Patient A., mild-to-moderate AD before (a) and after 4-week therapy with the study drug (b).

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6. Fig. 5. Patient B., mild-to-moderate AD before (a) and after 4-week therapy with the study drug (b).

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7. Fig. 6. Patient C., mild-to-moderate AD before (a) and after 4-week therapy with the study drug (b).

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