ACTUAL ASPECTS OF THE DIAGNOSIS AND TREATMENT OF HELMINTHIC INFESTATIONS. LECTURE


Cite item

Full Text

Abstract

At present the problem of worm infestation is quite common in clinical practice of primary care physicians (pediatricians). In Russia, up to 80 nosological species of helminths are detected and found. Helminths have certain adaptive mechanisms that allow them to effectively suppress the host’s immune system and exist in a macroorganism state. All helminthic invasions are characterized by a common clinical and pathogenetic stages. Clinical manifestations depend on the location of the helminth, the state of the macroorganism, and the activity of the process. For primary contact doctors, it is important to know the main indications for screening for helminth infections. Diagnostic algorithms are approved by the standards of the World Health Organization. The “gold standard” of diagnosis is helminthoproscopy. However, serological diagnostic methods can be used for tissue helminthiases, as well as in the diagnosis of the acute phase of the disease. In the treatment of helminthic infestations, anthelmintic drugs of the II and III generations are mainly used. In order to eliminate helminth infections transmitted through the soil, the new programme of preventive measures endemic areas will be launched by the World Health Organization in 2020. It includes, among other things, the prophylactic administration of anthelmintic drugs to children, such as mebendazole and albendazole.

Full Text

Restricted Access

About the authors

Boris M. Blokhin

Pirogov Russian National Research Medical University

Email: blokhinb@gmail.com

Anastasia D. Prokhorova

Pirogov Russian National Research Medical University

Aliya S. Suyundukova

Pirogov Russian National Research Medical University

Irina P. Lobushkova

Pirogov Russian National Research Medical University

References

  1. Brooker S, Clements AC, Bundy DA. Global epidemiology, ecology and control of soil-transmitted helminth infections Adv Parasitol 2006; 62: 221-61.
  2. Colley DG, LoVerde PT, Savioli L. Infectious disease. Medical helminthology in the 21st Century. Science 2001; 293 (5534): 1437-8. doi: 10.1126/science.1060733
  3. Управление Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека по г. Москве. Приказ №138 от 22.12.2014 г. «О порядке специального учета инфекционных и паразитарных заболеваний в Москве». @@Upravlenie Federal'noi sluzhby po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiia cheloveka po g. Moskve. Prikaz №138 ot 22.12.2014 g. "O poriadke spetsial'nogo ucheta infektsionnykh i parazitarnykh zabolevanii v Moskve" (in Russian).
  4. Онищенко Г.Г. Состояние заболеваемости паразитарными болезнями в 1998 году и меры по ее стабилизации в Российской Федерации. Мед. паразитология и паразитарные болезни. 2000; 1: 3-7. @@Onishchenko G.G. Sostoianie zabolevaemosti parazitarnymi bolezniami v 1998 godu i mery po ee stabilizatsii v Rossiiskoi Federatsii. Med. parazitologiia i parazitar-nye bolezni. 2000; 1: 3-7 (in Russian).
  5. Горохов В.В., Скира В.Н., Кленова И.Ф. и др. Современная эпизоотологическая ситуация по основным гельминтозам в РФ (2005 г.). Материалы докл. науч. конф. «Теория и практика борьбы с паразитарными болезнями». Вып. 8. М., 2007; с. 78-9. @@Gorokhov V.V., Skira V.N., Klenova I.F. et al. Sovremennaia epizootologicheskaia si-tuatsiia po osnovnym gel'mintozam v RF (2005 g.). Materialy dokl. nauch. konf. "Teoriia i praktika bor'by s parazitarnymi bolezniami". Vyp. 8. Moscow, 2007; p. 78-9 (in Russian).
  6. Research priorities for helminth infections. World Health Organization, TDR Disease Reference Group on Helminth Infections. World Health Organ Tech Rep Ser 2012; 972: xv-xvii, 1-174, back cover.
  7. Brooker S Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers - a review. J Parasitol 2010; 40 (10): 1137-44.
  8. Pullan RL, Smith JL, Jasrasaria R, Brooker S Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. J Parasit Vectors 2014; 7: 37.
  9. Chapter 87. Helminths: Pathogenesis and Defenses. In: Medical Microbiology. 4th edition. S.Baron, ed. Galveston (TX): University of Texas Medical Branch at Galveston, 1996.
  10. Maizels RM, Pearce EJ, Artis D et al. Regulation of pathogenesis and immunity in helminth infections. J Exp Med 2009; 206 (10): 2059-66. doi: 10.1084/jem.20091903
  11. Токмалаев А.К. Гельминтозы человека. РМЖ 2001; 16: 690. @@Tokmalaev A.K. Gel'mintozy cheloveka. RMZh 2001; 16: 690 (in Russian).
  12. Гаврилова Е.П., Кирпичникова Г.И., Кузнецов Н.И. и др. Гельминтозы: общая характеристика, диагностика, лечение. Рос. семейный врач. 2016; 4. @@Gavrilova E.P., Kirpichnikova G.I., Kuznetsov N.I. et al. Gel'mintozy: obshchaia kha-rakteristika, diagnostika, lechenie. Ros. semeinyi vrach. 2016; 4 (in Russian).
  13. Шрайнер Е.В. Гельминтозы в клинической практике. РМЖ. 2013; 20: 103. @@Shrainer E.V. Gel'mintozy v klinicheskoi praktike. RMZh. 2013; 20: 103 (in Russian).
  14. Мочалова А.А., Ершова И.Б. Взгляд на проблему гельминтозов и паразитозов на современном этапе. Актуальная инфектология. 2014; 2 (3). @@Mochalova A.A., Ershova I.B. Vzgliad na problemu gel'mintozov i parazitozov na so-vremennom etape. Aktual'naia infektologiia. 2014; 2 (3) (in Russian).
  15. Прохорова АД. Диагностика и терапия острых паразитарных заболеваний у детей. Участковый педиатр. 2019; 4: 2-3. @@Prokhorova A.D. Diagnostika i terapiia ostrykh parazitarnykh zabolevanii u detei. Uchastkovyi pediatr. 2019; 4: 2-3 (in Russian).
  16. Основные методы лабораторной диагностики паразитарных болезней. Женева: Всемирная организация здравоохранения, 1994. @@The main methods of laboratory diagnosis of parasitic diseases. Geneva: World Health Organization, 1994 (in Russian).
  17. Контроль и профилактика геогельминтозов в странах европейского региона ВОЗ. Сборник справочно-методических материалов. Под ред. ВДавидянца, Е.Черниковой, ВЛунгу. ВОЗ, 2017. @@Monitoring and prevention of geohelminthiasis in countries of the WHO European Region. Collection of reference and methodological materials. Ed. V.Davidy-ants, E.Chernikova, V.Lungu. WHO, 2017 (in Russian).
  18. Khurana S, Sethi S. Laboratory diagnosis of soil transmitted helminthiasis. Trop Pa-rasitol 2017; 7 (2): 86-91. doi: 10.4103/tp.TP_29_17
  19. ВОЗ. Информационный бюллетень. 2014; 366. @@VOZ. Informatsionnyi biulleten'. 2014; 366 (in Russian).
  20. ВОЗ. Информационный бюллетень. Гельминтные инфекции, передаваемые через почву. 14.03.2019. @@VOZ. Informatsionnyi biulleten'. Gel'mintnye infektsii, peredavaemye cherez po-chvu. 14.03.2019 (in Russian).

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74329 от 19.11.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies