Interferon clinical use: modern view on efficacy and safety. Literature review


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Abstract

Interferons (IFN) were find about 65 years ago and during this time it was studied structure, types, cells producing this cytokines and genes coding of IFN. It was paid a great attention to IFN functions and biologic role in anti-viral and anti-tumor immunity, and in systemic inflammatory and autoimmune reactions. By biologic effects, which arise in organism by IFN, administrations for IFN clinical use were formed: viral infections and malignancies therapy. Currently, proposed clinical IFN use are scale down, because of not only new (including targeted) drugs, but also increased reports about long-term side effects, caused by IFN. One of the most serious side effects are autoimmune disorders, which make us reconsider IFN therapy to more safety drugs.

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About the authors

Timur T. Valiev

Blokhin National Medical Research Center of Oncology

Email: timurvaliev@mail.ru
Moscow, Russia

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