Vitamin D supplementation in children with urinary tract infection

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Urinary tract infections (UTIs) are one of the most common bacterial infections in the global population. Vitamin D deficiency is also an urgent and common problem, and the high incidence of hypovitaminosis does not depend on age, sex, nationality, and geographical location. Along with the so-called "classical" effects of cholecalciferol, no less significant non-calcemic functions of cholecalciferol have been actively studied over the past two decades, particularly its effect on inflammation and its role in anti-infectious immunity. More and more data on the relationship between UTIs and vitamin D deficiency supports the possible use of cholecalciferol as an adjuvant to basic UTI therapy.

Aim. To analyze the vitamin D status in children with UTI compared to healthy ones.

Materials and methods. The study included 75 children from 1 month to 18 years with UTIs of various localization treated in a healthcare institution in Stavropol. The mean age of the study patients was 6.0±0.3 years. Vitamin D status was based on serum calcidiol [25(OH)D3] level.

Results. The vitamin D level is statistically significantly higher in children of the control group than in patients with UTI: 36.42 ng/mL [24.92–46.37] vs 24.13 ng/mL [13.75–36.42], respectively (p=0.003). There were no patients with severe vitamin deficiency in the control group, while in the UTI group, it occurred in 20.0% of patients. The vitamin D level was less than 20 ng/mL in 31 (41.3%) children with UTI and only 2 (6.6%) in the control group (p=0.001). Normal vitamin status was found in only 38.7% of patients with UTI compared to 66.7% of healthy children (p<0.01). The lowest level was found in patients with acute cystitis – 19.7 ng/mL [9.8–19.7], and the highest in patients with acute pyelonephritis – 31.9 ng/mL [14.3–36.4].

Conclusion. Based on the study results, it can be concluded that vitamin D deficiency may be one of the risk factors for developing UTIs in children. Further studies involving more patients are needed.

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作者简介

Anna Tsutsaeva

Stavropol State Medical University; Regional Children Clinical Hospital

编辑信件的主要联系方式.
Email: a.nicolaevnakasjanova@yandex.ru
ORCID iD: 0000-0002-9524-8724

Cand. Sci. (Med.)

俄罗斯联邦, Stavropol; Stavropol

Irina Zakharova

Russian Medical Academy of Continuous Professional Education

Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0003-4200-4598

Sci. (Med.), Prof.

俄罗斯联邦, Moscow

Leonid Klimov

Stavropol State Medical University

Email: klimov_leo@mail.ru
ORCID iD: 0000-0001-7248-1614

Sci. (Med.), Prof.

俄罗斯联邦, Stavropol

Artem Minasyan

Stavropol State Medical University

Email: artem.minasyan@inbox.ru
ORCID iD: 0000-0001-7519-8646

Graduate Student

俄罗斯联邦, Stavropol

Svetlana Dolbnya

Stavropol State Medical University; Regional Children Clinical Hospital

Email: svet-lana.dolbnya@yandex.ru
ORCID iD: 0000-0002-2056-153X

Cand. Sci. (Med.)

俄罗斯联邦, Stavropol; Stavropol

Victoriya Kuryaninova

Stavropol State Medical University

Email: vichkak@mail.ru
ORCID iD: 0000-0002-0731-7153

Cand. Sci. (Med.)

俄罗斯联邦, Stavropol

参考

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2. Fig. 1. Vitamin D status in the UTI group and the control group.

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