A clinical example of the effect of latent infection and chronic inflammation on urination disorders in a 12-year-old child without organic pathology. Case report

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Bladder dysfunctions of inorganic origin in childhood are found in 40% of visits to the doctor about urination disorders. In the practice of pediatricians, there are patients who do not respond well to basic treatment, and urination disorders persist for several years. Such patients are included in the group of frequently ill children, have frequent recurrences of urinary tract infections. This publication describes the conducted microbiological studies of patients by the method of chromatography-mass spectrometry of microbial markers. The expected results of latent microbial agents were obtained in the discharge from the pharynx, the contents of the intestinal lumen, and urinary sediment. The presence of infection in the surveyed regions contributed to the maintenance of a chronic inflammatory process. The conducted antimicrobial treatment contributed to the relief of inflammation and potentiated the basic therapy, which contributed to the effective correction of urinary disorders of inorganic origin in children.

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Timofei Bozhendaev

Pirogov Russian National Research Medical University; Speransky Children's City Clinical Hospital №9

编辑信件的主要联系方式.
Email: dr.bozhendaev@gmail.com
ORCID iD: 0000-0002-8819-0771

Cand. Sci. (Med.)

 

俄罗斯联邦, Moscow; Moscow

Albina Simonova

Vladimirsky Moscow Regional Research Clinical Institute; Academy of Medical and Technical Sciences of the Eurasian Association of Medical and Ecological Technologies

Email: medlabnews@mail.ru
ORCID iD: 0000-0001-9289-4010

Sci. (Med.), Prof.

俄罗斯联邦, Moscow; Moscow

Natalia Guseva

Pirogov Russian National Research Medical University; Speransky Children's City Clinical Hospital №9; Russian Medical Academy of Continuing Professional Education

Email: guseva-n-b@yandex.ru
ORCID iD: 0000-0002-1583-1769

Sci. (Med.)

俄罗斯联邦, Moscow; Moscow; Moscow

Sergei Nikitin

Petrozavodsk State University; Grigovich Children's Republican Hospital

Email: ssnikitin@yandex.ru
ORCID iD: 0000-0002-4920-1722

Sci. (Med.)

俄罗斯联邦, Petrozavodsk; Petrozavodsk

参考

  1. Гусева Н.Б., Никитин С.С. Нейрофизиологические аспекты расстройств мочеиспускания неорганического генеза у детей, основные принципы диагностики и лечения. Педиатрия им. Г.Н. Сперанского. 2017;96(5):1137-43 [Guseva NB, Nikitin SS. Neurophysiological aspects of urination disorders of inorganic genesis in children, main principles of diagnostics and treatment. Pediatria n.a. G.N. Speransky. 2017;96(5):1137-43 (in Russian)].
  2. Урсова Н.И. Особенности формирования микробиоценоза у грудных детей и дисбактериоз кишечника. Педиатрия. Consilium Medicum. 2005;7(2):56-9 [ Ursova NI. Features of microbiocenosis formation in infants and intestinal dysbacteriosis. Pediatrics. Consilium Medicum. 2005;7(2):56-9 (in Russian)].
  3. Епишина И.В., Буданова Е.В. Роль микробиоты человека в развитии нейродегенеративных заболеваний. Журнал неврологии и психиатрии им. С.С. Корсакова. 2022;122(10):57-65 [Epishina IV, Budanova EV. A role of human microbiota in the development of neurodegenerative diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10):5765 (in Russian)]. doi: 10.17116/jnevro202212210157
  4. Николаева И.В., Царегородцев А.Д., Шайхиева Г.С. Формирование кишечной микробиоты ребенка и факторы, влияющие на этот процесс. Российский вестник перинатологии и педиатрии. 2018;63(3):13-8 [Nikolaeva IV, Tsaregorodtsev AD, Shaikhieva GS. Formation of the intestinal microbiota if children and the factors that influence this process. Ros Vestn Perinatol i Pediatr. 2018;63(3):13-8 (in Russian)]. doi: 10.21508/1027-4065-2018-63-3-13-18
  5. Медведев Ю.В., Толстой А.Д. Гипоксия свободные радикалы в развитии патологических состояний организма. М.: Терра-Календер и промоушн, 2000 [Medvedev IuV, Tolstoi AD. Gipoksiia svobodnye radikaly v razvitii patologicheskikh sostoianii organizma. Moscow: Terra-Kalender i promoushn, 2000 (in Russian)].
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  7. Годков М.А., Осипов Г.А., Федосова Н.Ф., Лядов К.В. Возможности масс-спектрометрии микробных маркеров в лабораторном мониторинге дисбиозов и инфекций. Справочник заведующего КДЛ. 2011;(7):35-44 [Godkov MA, Osipov GA, Fedosova NF, Lyadov KV. Monitoring of infection and disbiosis in laboratory practice by mass-spectrometry of microbial markers. Spravochnik Zaveduyuschego KDL. 2011;(7):35-44 (in Russian)].
  8. Гострый А.В., Симонова А.В., Михайлова Н.А., и др. Хронический фарингит: этиология, патогенез, лечение. Новые подходы к оценке этиопатогенеза. Архив внутренней медицины. 2019;9(1):32-43 [Gostry AV, Simonova AV, Mikhailova NA, et al. Chronic pharyngitis: Etiology, pathogenesis, treatment. New approaches to the estimation of etiopatogenesis. The Russian Archives of Internal Medicine. 2019;9(1):32-43 (in Russian)]. doi: 10.20514/2226-6704-2019-9-1-32-43

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2. Fig. 1. Reference values of microorganisms in the test material by gas chromato- graphy-mass spectrometry, ×105 cells/g.

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3. Fig. 2. Results of the study of microbial markers in urine (description in the text).

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4. Fig. 3. Results of the study of microbial markers in feces (description in the text).

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5. Fig. 4. Uroflowmetry after treatment.

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