A clinical example of the effect of latent infection and chronic inflammation on urination disorders in a 12-year-old child without organic pathology. Case report

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Abstract

Bladder dysfunctions of inorganic origin in childhood are found in 40% of visits to the doctor about urination disorders. In the practice of pediatricians, there are patients who do not respond well to basic treatment, and urination disorders persist for several years. Such patients are included in the group of frequently ill children, have frequent recurrences of urinary tract infections. This publication describes the conducted microbiological studies of patients by the method of chromatography-mass spectrometry of microbial markers. The expected results of latent microbial agents were obtained in the discharge from the pharynx, the contents of the intestinal lumen, and urinary sediment. The presence of infection in the surveyed regions contributed to the maintenance of a chronic inflammatory process. The conducted antimicrobial treatment contributed to the relief of inflammation and potentiated the basic therapy, which contributed to the effective correction of urinary disorders of inorganic origin in children.

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About the authors

Timofei L. Bozhendaev

Pirogov Russian National Research Medical University; Speransky Children's City Clinical Hospital №9

Author for correspondence.
Email: dr.bozhendaev@gmail.com
ORCID iD: 0000-0002-8819-0771

Cand. Sci. (Med.)

 

Russian Federation, Moscow; Moscow

Albina V. Simonova

Vladimirsky Moscow Regional Research Clinical Institute; Academy of Medical and Technical Sciences of the Eurasian Association of Medical and Ecological Technologies

Email: medlabnews@mail.ru
ORCID iD: 0000-0001-9289-4010

Sci. (Med.), Prof.

Russian Federation, Moscow; Moscow

Natalia B. Guseva

Pirogov Russian National Research Medical University; Speransky Children's City Clinical Hospital №9; Russian Medical Academy of Continuing Professional Education

Email: guseva-n-b@yandex.ru
ORCID iD: 0000-0002-1583-1769

Sci. (Med.)

Russian Federation, Moscow; Moscow; Moscow

Sergei S. Nikitin

Petrozavodsk State University; Grigovich Children's Republican Hospital

Email: ssnikitin@yandex.ru
ORCID iD: 0000-0002-4920-1722

Sci. (Med.)

Russian Federation, Petrozavodsk; Petrozavodsk

References

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Supplementary files

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2. Fig. 1. Reference values of microorganisms in the test material by gas chromato- graphy-mass spectrometry, ×105 cells/g.

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3. Fig. 2. Results of the study of microbial markers in urine (description in the text).

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4. Fig. 3. Results of the study of microbial markers in feces (description in the text).

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5. Fig. 4. Uroflowmetry after treatment.

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