Characteristics of chronic non-bacterial osteomyelitis in children living in the Novosibirsk region
- 作者: Zatolokina A.O.1,2, Loskutova S.A.1, Belousova T.V.1,2, Blagitko N.E.2, Dagaeva A.M.1, Khrushchev S.E.3
-
隶属关系:
- Novosibirsk State Medical University
- Novosibirsk Regional Clinical Hospital
- Sobolev Institute of Mathematics
- 期: 编号 1 (2024)
- 页面: 88-93
- 栏目: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/633336
- DOI: https://doi.org/10.26442/26586630.2024.1.202686
- ID: 633336
如何引用文章
全文:
详细
Background. Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disease that has been insufficiently studied and described in the scientific medical literature. Due to the lack of specific laboratory and instrumental criteria, a complex interdisciplinary differential diagnosis is required.
Aim. To study the clinical manifestations of the onset of the disease, the features of the course, and the results of laboratory and instrumental diagnostic methods in pediatric patients living in the Novosibirsk region diagnosed with CNO.
Materials and methods. A retro- and prospective observational study was conducted, and inpatient records were analyzed in patients under 18 with a documented diagnosis of CNO, SAPHO syndrome, and hospitalized in the State Novosibirsk Regional Clinical Hospital departments.
Results. In the Novosibirsk region, relatively early detection of CNO is carried out, with an average diagnostic gap of about six months. Less than half (34%) of the patients from the observation group were referred to a pediatric rheumatologist at the initial visit for bone pain despite the presence of concomitant articular syndrome in most of them (70%). The most common affected area in CNO is the spine (30%), followed by the femur (19%) and pelvis (16%). Notably, at the onset of the disease, monofocal bone tissue lesions were common (52%). Pain and loss of function in the bone lesion area were typical complaints in all patients with CNO. Articular syndrome was also common.
Conclusion. CNO, being a rare autoinflammatory disease, requires a relatively complex multidiscipline differential diagnosis; its outcomes largely depend on the timing of the diagnosis.
全文:
作者简介
Anastasia Zatolokina
Novosibirsk State Medical University; Novosibirsk Regional Clinical Hospital
编辑信件的主要联系方式.
Email: a.o.zatolokina@gmail.com
ORCID iD: 0000-0002-6425-5024
Assistant of Professor
俄罗斯联邦, Novosibirsk; Novosibirsk
Svetlana Loskutova
Novosibirsk State Medical University
Email: a.o.zatolokina@gmail.com
ORCID iD: 0000-0003-2673-0880
Sci. (Med.), Prof.
俄罗斯联邦, NovosibirskTamara Belousova
Novosibirsk State Medical University; Novosibirsk Regional Clinical Hospital
Email: a.o.zatolokina@gmail.com
ORCID iD: 0000-0002-4234-9353
Sci. (Med.), Prof.
俄罗斯联邦, Novosibirsk; NovosibirskNatalia Blagitko
Novosibirsk Regional Clinical Hospital
Email: a.o.zatolokina@gmail.com
Cand. Sci. (Med.), Head Senior Pediatric Department
俄罗斯联邦, NovosibirskAnastasia Dagaeva
Novosibirsk State Medical University
Email: a.o.zatolokina@gmail.com
Resident, Novosibirsk State Medical University
俄罗斯联邦, NovosibirskSergei Khrushchev
Sobolev Institute of Mathematics
Email: a.o.zatolokina@gmail.com
Senior Res. Officer, Sobolev Institute of Mathematics
俄罗斯联邦, Novosibirsk参考
- Zhao Y, Dedeoglu F, Polly J, et al. Physicians’ Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis. Int J Rheumatol. 2017;7694942. doi: 10.1155/2017/7694942
- Cox J, Ferguson J. Update on the genetics of nonbacterial osteomyelitis in humans. Curr Opin Rheumatol. 2018;30(5):521-5. doi: 10.1097/BOR.0000000000000530
- D’Angelo P, Tanturri de Horatio L, Toma P. Chronic nonbacterial osteomyelitis – clinical and magnetic resonance imaging features. Pediatr Radiol. 2021;51:282-8. doi: 10.1007/S00247-020-04827-6
- Zhao Y, McCann L, Hahn G. Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO). J Transl Autoimmun. 2021;4:100095. doi: 10.1016/j.jtauto.2021.100095
- Chronic nonbacterial osteomyelitis. Chronic recurrent multifocal osteomyelitis. Available at: https://www.orpha.net/consor/cgi-bin/OC. Accessed: 15.02.2023.
- Koryllou A, Mejbri M, Theodoropoulou K. Chronic Nonbacterial Osteomyelitis in Children. Children. 2021;8:551. doi: 10.3390/children8070551
- Hofmann R, Böttger F, Range U, et al. Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis. Front Pediatr. 2017:5:256. doi: 10.3389/fped.2017.00256
- Roderick MR, Shah R, Rogers V, et al. Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis. Pediatr Rheumatol Online J. 2016;14(1):47. doi: 10.1186/s12969-016-0109-1
- Schnabel A, Range U, Hahn G, et al. Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2017;44(7):1058-65. doi: 10.3899/jrheum.161255
- Buch K, Thuesen AC, Brоns C, et al. Chronic Non-bacterial Osteomyelitis: A Review. Calcif Tissue Int. 2019;104(5):544-53. doi: 10.1007/S00223-018-0495-0
- Zhao Y, Wu Y, Oliver S, et al. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions. Arthritis Care Res (Hoboken). 2018;70(8):1228-37. doi: 10.1002/acr.23462
- Lenert A, Ferguson J. Comparing children and adults with chronic nonbacterial osteomyelitis. Curr Opin Rheumatol. 2020;32(5):421-6. doi: 10.1097/BOR.0000000000000734
- Concha S, Hernández, Ojeda A, Contreras O, et al. Chronic nonbacterial osteomyelitis in children: a multicenter case series. Rheumatol Int. 2020;40:115-20. doi: 10.1007/S00296-019-04400-X
- Assmann G, Köhm M, Schuster V, et al. Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups. BMC Med Genet. 2020;21:102. doi: 10.1186/s12881-020-01037-7
- Копчак О.Л., Костик М.М., Мушкин А.Ю. Хронический небактериальный («стерильный») остеомиелит в практике детского ревматолога, современные подходы к диагностике и лечению: обзор литературы и анализ собственных данных. Вопросы современной педиатрии. 2016;15(1):33-44 [Kopchak OL, Kostik MM, Mushkin AJ. Chronic non-bacterial («sterile») osteomyelitis in the practice of pediatric rheumatologist, the contemporary diagnostic and treatment approaches: literature review and own data analysis. Current pediatrics. 2016;15(1):33-44 (in Russian)]. doi: 10.15690/vsp.v15i1.1498
- Hofmann R, Kapplusch F, Girschick J. Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. Curr Osteopor Rep. 2017;15:542-54. doi: 10.1007/S11914-017-0405-9
- Cox AJ, Zhao Y, Ferguson PJ. Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis. Curr Rheumatol Rep. 2017;19(4):18. doi: 10.1007/s11926-017-0645-9
- Hedrich CM, Morbach H, Reiser C, et al. New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO. Curr Rheumatol Rep. 2020;22:52. doi: 10.1007/s11926-020-00928-1
- Zhao Y, Laxer RM, Ferguson PJ. Treatment Advances in Chronic Non-Bacterial Osteomyelitis and Other Autoinflammatory Bone Conditions. Pediatr Rheumatol. 2017;3:17-32. doi: 10.1007/s40674-017-0058-y
- Hofmann SR, Kapplusch F, Mäbert K, et al. The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO) – a systematic review. Mol Cell Pediatr. 2017;4:7. doi: 10.1186/s40348-017-0073-y