Prevention of iron deficiency conditions in obese children

封面

如何引用文章

全文:

详细

Background. Due to the progressive increase in childhood obesity, the effect of iron levels in the body on carbohydrate and lipid metabolism disorders and the relationship between these conditions are actively studied. It is proven that obesity in children is often associated with dysregulation of iron metabolism. The correlation between the body mass index and iron deficiency (ID) in children and adolescents was reported. Therefore, implementing preventive measures to correct the iron deficiency state (IDS), including the enrichment of the diet with foods containing easily digestible iron, is relevant and can be considered as one of the principles of an integrated approach to the treatment of obesity in childhood.

Aim. To evaluate the effectiveness of dietary supplements "Kidz Tasty iron" for IDS prevention in obese children.

Materials and methods. Thirty children aged 7–14 with exogenous constitutional obesity were followed up, 14 (47%) females and 16 (53%) males. All patients received a dietary supplement (DS), "Kidz Tasty iron," 10 mL once daily with meals according to the label for 1 month. The follow-up included data on signs and symptoms, medical history, evaluation of anthropometric data, evaluation of current nutrition status with the software "Optimal Nutrition 5.0", bioimpedance analysis of body composition, questionnaire on the assessment of ID symptoms and quality of life, general hematology and blood chemistry tests, validated for childhood.

Results. The diets of obese children in the study had low iron content (33.3% of patients), which justifies the need for additional iron supplementation. While taking the dietary supplement "Kidz Tasty Iron," there was a positive clinical trend: decreased symptoms related to ID and clinical signs of ID, improved overall well-being, and increased quality of life. The improvement of the body composition of the studied children was represented by preservation and an increase (20% of patients) in the active cell mass in the studied children. Laboratory tests of iron metabolism improved in 9 children (30%). Most children reported the good organoleptic properties of the product. Adherence to the DS was 96.7%.

Conclusion. The study results show the "Kidz Tasty iron" dietary supplement to be tolerable, safe, and effective, supporting its use in the complex therapy of children and adolescents with obesity, including for IDS prevention.

全文:

受限制的访问

作者简介

Oksana Mikhaleva

Vladimirsky Moscow Regional Research Clinical Institute; SM Clinic LLC

编辑信件的主要联系方式.
Email: ogmihaleva@mail.ru
ORCID iD: 0000-0002-9198-322X

Cand. Sci. (Med.)

俄罗斯联邦, Moscow; Moscow

Tatyana Bokova

Vladimirsky Moscow Regional Research Clinical Institute; Pirogov Russian National Research Medical University

Email: ogmihaleva@mail.ru
ORCID iD: 0000-0001-6428-7424

D. Sci. (Med.), Assoc. Prof.

俄罗斯联邦, Moscow; Moscow

Anna Bevz

Vladimirsky Moscow Regional Research Clinical Institute; Pirogov Russian National Research Medical University

Email: ogmihaleva@mail.ru
ORCID iD: 0000-0002-4954-4872

Res. Assist.

俄罗斯联邦, Moscow; Moscow

Daria Kartashova

Vladimirsky Moscow Regional Research Clinical Institute

Email: ogmihaleva@mail.ru
ORCID iD: 0000-0002-0005-7352

Res. Assist.

俄罗斯联邦, Moscow

Elena Shishulina

Vladimirsky Moscow Regional Research Clinical Institute

Email: ogmihaleva@mail.ru
ORCID iD: 0000-0002-4858-8240

Res. Assist.

俄罗斯联邦, Moscow

参考

  1. Долгов В.В., Луговская С.А., Почтарь М.Е., Федорова М.М. Лабораторная диагностика нарушений обмена железа. Учеб. пособие. М.: ГБОУ ДПО РМАПО, 2012 [Dolgov VV, Lugovskaia SA, Pochtar’ ME, Fedorova MM. Laboratornaia diagnostika narushenii obmena zheleza. Ucheb. posobie. Moscow: GBOU DPO RMAPO, 2012 (in Russian)].
  2. Бокова Т.А., Масликова Г.В. Железодефицитные состояния у подростков: принципы коррекции. Лечащий врач. 2014;9:49-51 [Bokova TA, Maslikova GV. Iron deficiency conditions in adolescents: Principles of correction. Lechashchii Vrach. 2014;9:49-51 (in Russian)].
  3. Румянцев А.Г., Захарова И.Н., Чернов В.М., и др. Лечение железодефицитной анемии у детей и подростков: основные принципы и наиболее частые ошибки. Педиатрия. 2015;94(5):114-9 [Rumyantsev AG, Zakharova IN, Chernov VM, et al. Treatment of iron deficiency anemia in children and adolescents: Basic principles and the most common mistakes. Pediatrics. 2015;94(5):114-9 (in Russian)].
  4. Cамороднова Е.А. Железодефицитные состояния у детей: современные аспекты проблемы, возможности первичной профилактики. Педиатрия. Consilium Medicum. 2022;4:302-8 [Samorodnova EA. Iron deficiency in children: modern aspects of the problem, possibilities of primary prevention: A review. Pediatrics. Consilium Medicum. 2022;4:302-8 (in Russian)]. doi: 10.26442/26586630.2022.4.201960
  5. Смирнова Н.Н., Куприенко Н.Б., Новикова В.П., Хавкин А.И. Обмен железа при ожирении у детей и подростков. Вопросы диетологии. 2021;11(1):44-9 [Smirnova NN, Kuprienko NB, Novikova VP, Khavkin AI. Iron metabolism in obese children and adolescents. Vopr. dietol. (Nutrition). 2021;11(1):44-9 (in Russian)]. doi: 10.20953/2224-5448-2021-1-44-49
  6. Huang YF, Tok TS, Lu CL, et al. Relationship between being overweight and iron deficiency in adolescents. Pediatr Neonatol. 2015;56(6):386-92. doi: 10.1016/j.pedneo.2015.02.003
  7. Grandone A, Marzuillo P, Perrone L, Del Giudice EM. Iron metabolism dysregulation and cognitive dysfunction in pediatric obesity: Is there a connection? Nutrients. 2015;7(11):9163-70. doi: 10.3390/nu7115458
  8. Ожирение у детей. Клинические рекомендации. 2021. Режим доступа: https://cr.minzdrav.gov.ru/schema/229_2. Ссылка активна на 05.07.2024 [Ozhirenie u detei. Klinicheskie rekomendatsii. 2021. Available at: https://cr.minzdrav.gov.ru/schema/229_2. Accessed: 05.07.2024 (in Russian)].
  9. Железодефицитная анемия. Клинические рекомендации. 2023. Режим доступа: https://cr.minzdrav.gov.ru/schema/669_1. Ссылка активна на 05.07.2024 [Zhelezodefitsitnaia anemiia. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/schema/669_1. Accessed: 05.07.2024 (in Russian)].
  10. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации. Методические рекомендации MP 2.3.1.0253-21 (утв. Федеральной службой по надзору в сфере защиты прав потребителей и благополучия человека 22 июля 2021 г.). Режим доступа: https://www.garant.ru/products/ipo/prime/doc/402716140/?ysclid=lxqn29ijwm679380937. Ссылка активна на 05.07.2024 [Normy fiziologicheskikh potrebnostei v energii i pishchevykh veshchestvakh dlia razlichnykh grupp naseleniia Rossiiskoi Federatsii. Metodicheskie rekomendatsii MP 2.3.1.0253-21 (utv. Federal’noi sluzhboi po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiia cheloveka 22 iiulia 2021 g.). Available at: https://www.garant.ru/products/ipo/prime/doc/402716140 /?ysclid=lxqn29ijwm679380937. Accessed: 05.07.2024 (in Russian)].
  11. Диагностика и лечение железодефицитной анемии у детей и подростков (пособие для врачей). Под ред. акад. РАН, проф. А.Г. Румянцева и проф. И.Н. Захаровой. М., 2015 [Diagnostika i lechenie zhelezodefitsitnoi anemii u detei i podrostkov (posobie dlia vrachei). Pod red. akad. RAN, prof. AG Rumiantseva i prof. IN Zakharovoi. Moscow, 2015 (in Russian)].
  12. Zhao P, Stephens JM. STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes. Mol Metab. 2013;2(3):161-70. doi: 10.1016/j.molmet.2013.04.003
  13. Дворецкий Л.И., Ивлева О.В. Ожирение как фактор риска нарушения обмена железа. Медицинский совет. 2015;(17):144-8 [Dvoretskiy LI, Ivleva OV. Obesity is a risk factor for iron metabolism disorder. Medical Council. 2015;(17):144-8 (in Russian)]. doi: 10.21518/2079-701X-2015-17-144-148

补充文件

附件文件
动作
1. JATS XML
2. Fig. 1. Changes in the quality of life of children and adolescents before and after “Kidz Tasty iron” supplementation, *p<0.05.

下载 (58KB)

版权所有 © Consilium Medicum, 2024

Creative Commons License
此作品已接受知识共享署名-非商业性使用-相同方式共享 4.0国际许可协议的许可。

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74329 от 19.11.2018 г.