Age-related changes in heart rate variability from the neonatal period to adulthood

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The aim of the study was to reveal the regularities of the age-related dynamics of the frequency-dependent regulation of heart rate variability (HRV) based on the analysis of Holter ECG recordings from healthy subjects of 4 age groups: neonates, one-year-old infants, adolescents and adults. A wide spectral composition of HRV is shown, consisting of 9 Gilbert-Huang modes in the frequency range from 0.0001 to 2 Hz. A decrease in the central frequencies of all modes is shown in the postnatal period with a plateau in adolescence. A rapid progression of systemic humoral regulation of HRV, characterized by a consolidated increase in the amplitudes of the corresponding modes with a plateau in adolescence, is demonstrated. The dome-shaped character of age-related changes in amplitude of modes associated with autonomic control with a maximum in adolescence is shown. The results obtained quantitatively demonstrate age-related consolidated changes in HRV parameters from neonates to adulthood.

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作者简介

A. Grinevich

Institute of Cell Biophysics of Russian Academy of Sciences

编辑信件的主要联系方式.
Email: grin_aa@mail.ru
俄罗斯联邦, Pushchino

N. Chemeris

Institute of Cell Biophysics of Russian Academy of Sciences

Email: grin_aa@mail.ru
俄罗斯联邦, Pushchino

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2. Fig. 1. Spectral curves of empirical HRV modes in adolescents (11-17 years old, g3). The data is presented as the median and the 25 and 75 percentiles. The numbers on the charts are mod numbers.

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3. Fig. 2. Maxima and corresponding frequencies for spectral curves of empirical HRV modes for different age groups. The data is presented as the median and the 25 and 75 percentiles. The numbers on the graph are mod numbers.

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