A ONE-TRIAL MOUSE MODEL OF TRAUMA-INDUCED LONG-TERM MEMORY

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Abstract

The formation and maintenance of memory throughout life remains one of the central unsolved problems in neuroscience. Although many experimental models have been developed to study memory, there is currently a lack of paradigms that would allow for reliably investigating the mechanisms underlying highly stable memory over timescales comparable to the lifespan. In this study, we examined the ability of mice to form highly stable long-term memory using a contextual fear conditioning paradigm, an adapted model of post-traumatic stress disorder (PTSD) with varying intensities of aversive stimulation. We developed a one-trial learning model in which mice reliably formed long-term associative memories that persisted for at least six months, demonstrating a promising tool for investigating mechanisms of memory retention across the lifespan.

About the authors

T. A Zamorina

Institute for Advanced Brain Studies, Lomonosov Moscow State University; Lomonosov Moscow State University

Email: tatazamorina@gmail.ru
Department of Higher Nervous Activity, Faculty of Biology Moscow, Russian Federation; Moscow, Russian Federation

K. A Toropova

Institute for Advanced Brain Studies, Lomonosov Moscow State University

Moscow, Russian Federation

O. I Ivashkina

Institute for Advanced Brain Studies, Lomonosov Moscow State University

Moscow, Russian Federation

K. V Anokhin

Institute for Advanced Brain Studies, Lomonosov Moscow State University

Academician of the RAS Moscow, Russian Federation

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