THE HUMAN TREX-2 COMPLEX INTERACTS WITH SUBUNITS OF THE ORC COMPLEX

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Аннотация

The TREX-2 protein complex is the key complex involved in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a joint protein complex of TREX-2 with ORC was isolated in D. melanogaster, it was shown that the interaction of TREX-2 with ORC is necessary for efficient mRNA export from the nucleus to the cytoplasm. In this work, we show that the TREX2-ORC joint complex is also formed in human cells.

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Авторлар туралы

M. Kurshakova

Institute of Molecular Biology RAS

Хат алмасуға жауапты Автор.
Email: kursha@mail.ru
Russian Federation, Moscow

S. Georgieva

Institute of Molecular Biology RAS

Email: kursha@mail.ru
Russian Federation, Moscow

D. Kopytova

Institute of Molecular Biology RAS

Email: kursha@mail.ru
Russian Federation, Moscow

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© М.М. Куршакова, С.Г. Георгиева, Д.В. Копытова, 2023