Innovations in the dietary therapy of cow's milk protein allergy: enrichment of highly hydrolyzed infant formulas with human milk oligosaccharides: A review

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The prevalence of food allergies has been increasing over the past 30 years. One of the most common causes of food allergies in children today is an allergy to cow's milk proteins (ACMP). Diagnosis of the ACMP can often be difficult, given the pathomorphism of the manifestations. Both in the diagnosis and in the treatment of children with manifestations of ACMP, a rejection of any dairy products and, consequently, the selection of a complete substitute to maintain a diet adequate in composition, action and caloric content is required. The use of highly hydrolyzed and amino acid formulas in the nutrition of children with ACMP is preferable, given the current opportunities that bring adapted formulas closer to the composition of breast milk, using breast milk oligosaccharides to support the development of early oral tolerance.

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Irina N. Zakharova

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
ORCID iD: 0000-0003-4200-4598

D. Sci. (Med.), Prof., Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow

Ismail M. Osmanov

Bashlyaeva Children's City Clinical Hospital; Pirogov Russian National Research Medical University

ORCID iD: 0000-0003-3181-9601

D. Sci. (Med.), Prof., Bashlyaeva Children's City Clinical Hospital, Pirogov Russian National Research Medical University

Russian Federation, Moscow; Moscow

Irina V. Berezhnaya

Russian Medical Academy of Continuous Professional Education

ORCID iD: 0000-0002-2847-6268

Cand. Sci. (Med.), Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow

Diana K. Dmitrieva

Russian Medical Academy of Continuous Professional Education

ORCID iD: 0000-0002-1593-0732

Graduate Student, Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow

Ekaterina V. Skorobogatova

Bashlyaeva Children's City Clinical Hospital


Cand. Sci. (Med.), Bashlyaeva Children's City Clinical Hospital

Russian Federation, Moscow

Anastasiia D. Gostiukhina

Russian Medical Academy of Continuous Professional Education


Medical Resident, Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. Algorithm for choosing a formula for a child with an allergy to cow's milk proteins.

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