Email this article Mechanisms of formation of cow's milk protein allergy: a clinical case in a breastfed infant
- Authors: Zakharova I.N.1, Dmitrieva D.K.1, Osmanov I.M.2, Skorobogatova E.V.2, Berezhnaya I.V.1
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Affiliations:
- Russian Medical Academy of Continuing Professional Education
- Bashlyaeva Children's City Clinical Hospital
- Issue: No 4 (2023)
- Pages: 226-230
- Section: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/627391
- DOI: https://doi.org/10.26442/26586630.2023.4.202565
- ID: 627391
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Abstract
Cow's milk protein allergy (CMPA) is one of the urgent problems of modern health care, which pediatricians often encounter in their practice. CMPA imposes a burden on babies and their mothers, forcing them to limit their diet and plan the family budget, taking into account the cost of therapeutic infant formulas. Also, CMPA is still a challenging diagnosis since it can present in three variants and has various developing mechanisms. The elimination diet is the most reliable test in an infant with suspected CMPA. All dietary restrictions are imposed on the mother if the baby receives breast milk. The article presents a clinical case of CMPA in a breastfed infant, which occurred when a formula was included in the diet and presented with rashes, mucus diarrhea, constipation, and projectile vomiting.
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About the authors
Irina N. Zakharova
Russian Medical Academy of Continuing Professional Education
Author for correspondence.
Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0003-4200-4598
D. Sci. (Med.), Prof
Russian Federation, MoscowDiana K. Dmitrieva
Russian Medical Academy of Continuing Professional Education
Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0002-1593-0732
Graduate Student
Russian Federation, MoscowIsmail M. Osmanov
Bashlyaeva Children's City Clinical Hospital
Email: dgkb-bashlyaevoy@zdrav.mos.ru
ORCID iD: 0000-0003-3181-9601
D. Sci. (Med.), Prof.
Russian Federation, MoscowEkaterina V. Skorobogatova
Bashlyaeva Children's City Clinical Hospital
Email: zakharova-rmapo@yandex.ru
Cand. Sci. (Med.)
Russian Federation, MoscowIrina V. Berezhnaya
Russian Medical Academy of Continuing Professional Education
Email: berezhnaya-irina26@yandex.ru
ORCID iD: 0000-0002-2847-6268
Cand. Sci. (Med.)
Russian Federation, MoscowReferences
- Walkner M, Warren C, Gupta RS. Quality of life in food allergy patients and their families. Pediatr Clin North Am. 2015;62(6):1453-61. doi: 10.1016/j.pcl.2015.07.003
- Lieberman JA, Sicherer SH. Quality of life in food allergy. Curr Opin Allergy Clin Immunol. 2011;11(3):236-42. doi: 10.1097/ACI.0b013e3283464cf0
- Koletzko S, Niggemann B, Arato A, et al. Diagnostic approach and management of cow’s-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines. J Pediatr Gastroenterol Nutr. 2012;55:221-9. doi: 10.1097/MPG.0b013e31825c9482
- Høst A. Frequency of cow’s milk allergy in childhood. Ann Allergy Asthma Immunol. 2002;89(6 Suppl. 1):33-7. doi: 10.1016/S1081-1206(10)62120-5
- Vandenplas Y. Prevention and management of cow’s milk allergy in non-exclusively breastfed infants. Nutrients. 2017;9(7):731. doi: 10.3390/nu9070731
- Wal JM. Allergies alimentaires: mecanismes physiopathologiques, identification des allergenes alimentaires. Nutr Clin Metabol. 2004;18:15-9.
- Rioardan J, Auerbach KG. Breastfeeding and human lactation. 2nd ed. Sudbury: Jones and Bartlett, 1999.
- Dutau G. Allergologie. Elsevier-Masson: Coll Abreges de medicine, 2006.
- Fiocchi A, Brozek J, Schunemann H, et al. World Allergy Organization (WAO) diagnosis and rationale for action against cow’s milk allergy (DRACMA) guidelines. Pediatr Allergy Immunol. 2010;21 Suppl. 21:1-125. doi: 10.1111/j.1399-3038.2010.01068.x
- Rance´ F, Bidat E, Dutau G. Diet for mother and infant and allergy prevention. Arch Pediatr. 2009;16:385-6. doi: 10.1016/j.arcped.2008.12.029
- Paupe J, Paty E, De Blic J, Scheinmann P. L’allergie au lait de vache du nourrisson. Rev Fr Allergol Immunol Clin. 2001;41:424-36.
- Rance´ F, Dutau G. Actualite´s sur l’exploration et la prise encharge de l’allergie aux proteines du lait de vache (APLV). Rev Fr Allergol. 2009;49(Suppl. 1):28-33.
- Høst A, Husby S, Osterballe O. A prospective study of cow’s milk allergy in exclusively breast-fed infants. Incidence, pathogenetic role of early inadvertent exposure to cow’s milk formula, and characterization of bovine milk protein in human milk. Acta Paediatr Scand. 1988;77(5):663-70. doi: 10.1111/j.1651-2227.1988.tb10727.x
- Vadas P, Wai Y, Burks W, Perelman B. Detection of peanut allergens in breast milk of lactating women. JAMA. 2001;285(13):1746-8. doi: 10.1001/jama.285.13.1746
- Palmer DJ, Gold MS, Makrides M. Effect of cooked and raw egg consumption on ovalbumin content of human milk: a randomized, double-blind, cross-over trial. Clin Exp Allergy. 2005;35(2):173-8. doi: 10.1111/j.1365-2222.2005.02170.x
- Denis M, Loras-Duclaux I, Lachaux A. Cow’s milk protein allergy through human milk. Arch Pediatr. 2012;19(3):305-12. doi: 10.1016/j.arcped.2011.12.002
- Adel-Patient K, Bernard H, Wal JM. Devenir des allergenes dansletube digestif. Rev Fr Allergol Immunol Clin. 2008;48:335-43.
- Schnell S, Herman RA. Should digestion assays be used to estimate persistence allergens in tests for safety of novel food proteins? Clin Mol Allergy. 2009;7:1. doi: 10.1186/1476-7961-7-1.
- Axelsson I, Jakobsson I, Lindberg T, Benediktsson B. Bovine beta-lactoglobulin in the human milk. A longitudinal study during the whole lactation period. Acta Paediatr Scand. 1986;75(5):702-7. doi: 10.1111/j.1651-2227.1986.tb10277.x
- D’Auria E, Salvatore S, Pozzi E, et al. Cow’s milk allergy: immunomodulation by dietary intervention. Nutrients. 2019;11(6):1399. doi: 10.3390/nu11061399
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