Gluten-related disorders: wheat allergy and non-celiac gluten sensitivity

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Abstract

Gluten-related disorders have gradually turned into an epidemiologically significant phenomenon, attracting the attention of the scientific community. Although they have specific pathogenetic pathways, they present with similar clinical manifestations, which makes their differential diagnosis challenging. The review presents current data on wheat allergy and non-celiac gluten sensitivity. Although wheat allergy is clearly defined by clinical forms and the diagnosis is based on specific diagnostic criteria, the diagnosis of non-celiac gluten sensitivity, on the contrary, can be considered only after excluding celiac disease and wheat allergy. This article describes a practical methodological approach to studying differences in the clinical presentation and diagnosis of gluten-dependent diseases.

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About the authors

Altinoy T. Kamilova

Republican Specialized Scientific Practice Medical Center of Pediatrics

Author for correspondence.
Email: okamilova@mail.ru
ORCID iD: 0000-0003-1695-0978

D. Sci. (Med.), Prof.

Uzbekistan, Tashkent

Noiba D. Azimova

Republican Specialized Scientific Practice Medical Center of Pediatrics

Email: okamilova@mail.ru
ORCID iD: 0000-0002-2435-7093

Res. Assist.

Uzbekistan, Tashkent

Irina N. Zakharova

Russian Medical Academy of Continuing Professional Education

Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0003-4200-4598

D. Sci. (Med.), Prof.

Russian Federation, Moscow

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2. Fig. 1. Clinical presentation of non-celiac gluten sensitivity and their frequency [30].

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