Email this article Post-COVID syndrome in children: the results of a retrospective multicenter cross-sectional study
- Authors: Tsarkova S.A.1, Zaytseva O.V.2, Lokshina E.E.2, Zaytseva S.V.2,3, Isaeva E.P.2,3, Murtazaeva O.A.2, Ermakova M.K.4, Pavlinova E.B.5, Vavilova V.P.6, Petrushina A.D.7, Faizullina R.M.8, Shangareeva Z.A.8, Bochkareva N.M.9, Yashkina O.N.9, Peterson K.I.1, Selivanov A.A.1, Shikina E.A.1, Kaib I.D.7, Kulichenko M.P.7, Khalidullina O.I.7, Ushakova S.A.7
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Affiliations:
- Ural State Medical University
- Russian University of Medicine
- Federal Research and Clinical Center for Children and Adolescents
- Izhevsk State Medical Academy
- Omsk State Medical University
- Kemerovo State Medical University
- Tyumen State Medical University
- Bashkir State Medical University
- Samara State Medical University
- Issue: No 1 (2024)
- Pages: 55-63
- Section: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/633330
- DOI: https://doi.org/10.26442/26586630.2024.1.202688
- ID: 633330
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Abstract
Background. Currently, there are no multicenter studies to determine the prevalence and incidence of symptoms of post-COVID syndrome (PCS) in children in different age groups, to develop consistent observation algorithms, and to identify therapy options.
Aim. To establish the risk factors for PCS in children and its CSs in the Russian Federation.
Materials and methods. A retrospective multicenter cross-sectional study was conducted. The initial stage of the study included 565 children at 7.6±0.17 months after the new coronavirus infection (NCVI) who were on outpatient or inpatient observation in different regions of Russia from November 2022 to May 2023. Patients were selected from 9 regions of the Russian Federation, such as Izhevsk, Kemerovo, Moscow, Omsk and Omsk region, Yekaterinburg and Sverdlovsk region, Ufa, Tyumen, Samara, Naberezhnye Chelny. All patients were offered a questionnaire. The questionnaire was developed and adapted based on the British and American consensus on the PCS, which included an assessment of the history, severity of the disease, clinical form of acute NCVI, therapy in the acute period of NCVI, and the presence of comorbidities. In addition, the course of acute NCVI and symptoms 3 months after the disease were evaluated by the following groups of CS: asthenia, respiratory disorders (RD), gastrointestinal disorders (GI), neurocognitive disorders (NCD), skin/adnexal lesions, olfactory/taste disorders, autonomic dysfunction (AD), anxiety. Of the 565 questionnaires received, 435 (76.9%) met the inclusion criteria and were available for subsequent analysis. The mean age was 9.0±0.25 years.
Results. During the acute period of the NCVI, asthenic syndrome (AS), RD and NCD, anxiety symptoms, olfactory/taste disorders, manifestations of AD, GI and skin/adnexal lesions were most often detected. Our study showed that after 3 months or more after NKVI, AS, NCD, and RD recurred in almost half of the observed children (53.1, 49.0 and 47.8%, respectively), anxiety was detected in 42,5% of cases, in more than 1/5 of children, AD, olfactory/taste and gastrointestinal disorders, in 14.3% skin/appendage lesions. Even 90 days after recovery from NCVI, more than half of patients reported impaired functionality, and most children had multiple complaints, which significantly impaired their quality of life. The risk of developing certain manifestations of PCS was increased in patients with comorbidities.
Conclusion. The study found that PCS developed in patients with severe, moderate, and mild acute COVID-19. The presence of comorbidities (allergic, neurological diseases, ENT disorders) statistically significantly increased the risk of PCS. The study's results further confirm the importance of continuous monitoring of NKVI sequelae in children and adolescents and the need for follow-up in children recovered from NKVI for 3-12 months.
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About the authors
Sofya A. Tsarkova
Ural State Medical University
Author for correspondence.
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0003-4588-5909
Sci. (Med.), Prof., Ural State Medical University
Russian Federation, Ekaterinburg
Olga V. Zaytseva
Russian University of Medicine
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0003-3426-3426
Sci. (Med.), Prof., Russian University of Medicine
Russian Federation, MoscowEvelina E. Lokshina
Russian University of Medicine
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0001-6006-7846
Cand. Sci. (Med.), Russian University of Medicine
Russian Federation, MoscowSvetlana V. Zaytseva
Russian University of Medicine; Federal Research and Clinical Center for Children and Adolescents
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0003-1685-234X
Cand. Sci. (Med.), Russian University of Medicine
Russian Federation, Moscow; MoscowElena P. Isaeva
Russian University of Medicine; Federal Research and Clinical Center for Children and Adolescents
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0003-0927-0288
Cand. Sci. (Med.), Russian University of Medicine
Russian Federation, Moscow; MoscowOlga A. Murtazaeva
Russian University of Medicine
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0001-6533-099X
Cand. Sci. (Med.), Russian University of Medicine
Russian Federation, MoscowMargarita K. Ermakova
Izhevsk State Medical Academy
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0001-8780-2994
Sci. (Med.), Prof., Izhevsk State Medical Academy
Russian Federation, IzhevskElena B. Pavlinova
Omsk State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0002-6444-1871
Sci. (Med.), Prof., Omsk State Medical University
Russian Federation, OmskVera P. Vavilova
Kemerovo State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0001-8056-7274
Sci. (Med.), Kemerovo State Medical University
Russian Federation, KemerovoAntonina D. Petrushina
Tyumen State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0003-1567-3710
Sci. Prof., (Med.), Prof., Tyumen State Medical University
Russian Federation, TymenReseda M. Faizullina
Bashkir State Medical University
Email: tsarkova_ugma@bk.ru
Sci. (Med.), Bashkir State Medical University.
Russian Federation, UfaZiliya A. Shangareeva
Bashkir State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0001-8745-9989
Cand. Sci. (Med.), Assoc. Prof., Bashkir State Medical University
Russian Federation, UfaNataliya M. Bochkareva
Samara State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0002-2890-2116
Cand. Sci. (Med.), Assoc. Prof., Samara State Medical University
Russian Federation, SamaraOlga N. Yashkina
Samara State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0002-8234-9809
Assistant, Samara State Medical University
Russian Federation, SamaraKristina Iu. Peterson
Ural State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0009-0002-4053-101X
Student, Ural State Medical University
Russian Federation, EkaterinburgArtem A. Selivanov
Ural State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0009-0000-6992-8198
Student, Ural State Medical University
Russian Federation, EkaterinburgElizaveta A. Shikina
Ural State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0009-0001-6539-5272
Student, Ural State Medical University
Russian Federation, EkaterinburgIrina D. Kaib
Tyumen State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0009-0009-8009-7052
Cand. Sci. (Med.)
Russian Federation, TymenMarija P. Kulichenko
Tyumen State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0009-0001-8670-9066
Cand. Sci. (Med.)
Russian Federation, TymenOksana Iu. Khalidullina
Tyumen State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0002-1004-3253
Cand. Sci. (Med.), Assoc. Prof.
Russian Federation, TymenSvetlana A. Ushakova
Tyumen State Medical University
Email: tsarkova_ugma@bk.ru
ORCID iD: 0000-0002-1667-3221
Sci. (Med.), Assoc. Prof., Tyumen State Medical University
Russian Federation, Tymen
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