Dysanapsis and its role in the occurrence of chronic obstructive respiratory diseases in children and adults: A review
- 作者: Khramova R.N.1, Eliseeva T.I.1, Tush E.V.1, Karpenko M.A.2, Ovsyannikov D.Y.2
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隶属关系:
- Volga Region Research Medical University
- People’s Friendship University of Russia (RUDN University)
- 期: 编号 3 (2023)
- 页面: 153-158
- 栏目: Articles
- URL: https://pediatria.orscience.ru/2658-6630/article/view/603047
- DOI: https://doi.org/10.26442/26586630.2023.3.202313
- ID: 603047
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The literature review, written on the basis of world literature data and the results of the authors' own research, is devoted to an important pathogenetic mechanism of development and progression of chronic obstructive pulmonary diseases in children and adults – dysanapsis, which is understood as a mismatch in the size or growth of the airways to the volume or growth of the lung parenchyma, while the diameter of the airways is disproportionately smaller than the volume of the lung parenchyma. Modern methods of diagnosis of dysanapsis are based on the use of computed tomography of the chest organs, spirometry (accounting for the volume of forced exhalation in 1 second, forced vital capacity of the lungs, calculation of the coefficient of dysanapsis). Dysanapsis, which has genetic and age-dependent mechanisms of formation, makes an important contribution to the development of bronchial hyperreactivity and bronchial asthma, especially in combination with overweight and obesity, determining the uncontrolled course of asthma. The phenomenon of dysanapsis can be explained by the clinical and functional indicators of the respiratory system (hypoxemia, bronchial obstruction) in premature infants, including patients with bronchopulmonary dysplasia, patients with postinfectious obliterating bronchiolitis. In addition, imbalance is an important pathogenetic component of chronic obstructive pulmonary disease, causing the defeat of patients with this disease, regardless of the presence and length of smoking.
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Regina Khramova
Volga Region Research Medical University
编辑信件的主要联系方式.
Email: reg1705@yandex.ru
ORCID iD: 0000-0002-2396-5054
Graduate Student, Volga Region Research Medical University
俄罗斯联邦, Nizhny NovgorodTatyana Eliseeva
Volga Region Research Medical University
Email: eliseevati@yandex.ru
ORCID iD: 0000-0002-1769-3670
D. Sci. (Med.), Assoc. Prof., Volga Region Research Medical University
俄罗斯联邦, Nizhny NovgorodElena Tush
Volga Region Research Medical University
Email: ltus@mail.ru
ORCID iD: 0000-0002-5961-9794
Cand. Sci. (Med.), Volga Region Research Medical University
俄罗斯联邦, Nizhny NovgorodMaxim Karpenko
People’s Friendship University of Russia (RUDN University)
Email: karpenko.ma@mail.ru
ORCID iD: 0000-0001-7937-722X
Cand. Sci. (Med.), People’s Friendship University of Russia (RUDN University)
俄罗斯联邦, MoscowDmitriy Ovsyannikov
People’s Friendship University of Russia (RUDN University)
Email: mdovsyannikov@yahoo.com
ORCID iD: 0000-0002-4961-384X
D. Sci. (Med.), People’s Friendship University of Russia (RUDN University)
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